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https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/self-microemulsifying-drug-delivery-system
Himanshu Agrawal, ... Ambikanandan Misra, in Challenges in Delivery of Therapeutic Genomics and Proteomics, 2011. 11.5.7 Microemulsions. Microemulsions, self-microemulsifying drug delivery systems (SMEEDS), and their parent drug delivery system, that is, emulsions, all come under a single closely related type of drug delivery system, in other words, they are oil-in-water or water-in-oil ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617838/
Jul 05, 2019 · The purposes of the present study were to: (1) develop a novel solid self-microemulsifying drug delivery system (SMEDDS) formulation of MTX via spray drying with calcium silicate as the solid carrier and (2) evaluate whether the solid SMEDDS improved …Author: Dong Shik Kim, Jung Hyun Cho, Jong Hyuck Park, Jung Suk Kim, Eon Soo Song, Jaewook Kwon, Bhupendra R...
https://link.springer.com/article/10.1007%2Fs11051-019-4744-6
Jan 04, 2020 · Self-microemulsifying drug delivery system (SMEDDS) is a uniform and transparent solution consisting of oil phase, surfactant, co-surfactant, and a small amount of water. It could be orally administered under gastrointestinal peristalsis and spontaneously dispersed to form an oil-in-water microemulsion with typical particle sizes lower than 100 nm.Author: Beibei Yan, Yingying Ma, Juan Guo, Yancai Wang
https://www.tandfonline.com/doi/pdf/10.3109/10717544.2014.896058
Self-microemulsifying drug delivery system (SMEDDS) – challenges and road ahead Shambhu Dokania* and Amita K. Joshi* Department of Pharmaceutics, NIPER Ahmedabad, C/o B.V. Patel PERD Centre, Ahmedabad, Gujarat, India Abstract Self-microemulsifying drug delivery system (SMEDDS) has emerged as a vital strategy to
https://www.sciencedirect.com/science/article/pii/S0378517320301186
In this study, we aimed to develop and characterize an optimal self-microemulsifying delivery system (SMEDS) formulated for 5-DTAN and to assess its anticancer activity in a xenograft model. SMEDS is a lipid-based formulation and typically comprises oil, surfactant, and co-surfactant.Author: Ya-Chun Chou, Shiming Li, Chi-Tang Ho, Min-Hsiung Pan, Min-Hsiung Pan, Min-Hsiung Pan
https://www.hindawi.com/journals/isrn/2014/964051/
Ease of administration and painless approach made oral route the most preferred. Poor oral bioavailability is pronounced with the majority of recent active ingredients because of dissolution rate limited absorption. Failure to attain intended therapeutic effect of the poor water soluble drugs by this route led to development of novel drug delivery systems which will fulfill therapeutic needs ...Author: Samatha Akula, Aravind Kumar Gurram, Srinivas Reddy Devireddy
https://pdfs.semanticscholar.org/746a/5a974d3cea1c584e8e80b1ef4a51c952e2a2.pdf
The oral delivery of lipophilic drugs presents a major challenge because of the low aqueous solubility of such compounds. Self-microemulsifying drug delivery systems (SMEDDSs) have gained exposure for their ability to increase solubility and bioavailability of poorly soluble drugs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674636/
Feb 06, 2015 · The drug has better antidepressant effect, achieved by acting on the 5-hydroxytryptamine receptor. However, the therapeutic effects of the drug are compromised due to its poor water solubility and lower bioavailability. Herein, a self-microemulsifying drug delivery system (SMEDDS) was developed to improve its solubility and oral bioavailability.Author: Lan Wu, Yanli Qiao, Lina Wang, Jiahua Guo, Guocheng Wang, Wei He, Lifang Yin, Jinhua Zhao
https://www.slideshare.net/sagarsavale1/self-micro-emulsifying-drug-delivery-system
Sep 06, 2015 · Conclusion Self-microemulsifying drug delivery system is a novel approach for the formulation of drug compounds with poor aqueous solubility. Self micro emulsifying drug delivery systems (SMEDDS) are mixtures of oils, Cosolvents and surfactants, which is isotropic in nature.
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