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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112363/
Nov 17, 2016 · Delivery of dsRNA using chemically modified molecules, polymer nanoparticles, liposomes, viruses or bacteria, could increase efficacy in attaining a potent RNAi response. The choice of the delivery method and the choice of formulation would of course depend on the circumstances, on the target insect and on the reason for impaired RNAi-efficiency.Author: Mallikarjuna R. Joga, Moises J. Zotti, Guy Smagghe, Olivier Christiaens
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Systemic Delivery. The site of action of siRNA therapeutics is the cytosol. The barriers to siRNA delivery are multiple and depend on the targeted organs and the administration routes. In general, locoregional delivery of siRNA has fewer barriers compared to systemic delivery.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.sciencedirect.com/science/article/pii/S1525001616319864
Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics. ... Currently, lipid nanoparticles (LNPs) represent the most advanced platform for the systemic delivery of siRNAs, and recent clinical data suggest that LNP-mediated RNAi therapeutics may soon be a reality.Author: Martin A Maier, Muthusamy Jayaraman, Shigeo Matsuda, Ju Liu, Scott Barros, William Querbes, Ying K T...
https://www.sciencedirect.com/science/article/pii/S1818087614000646
However, the excellent therapeutic potential of siRNA for cancer therapy remains uncovered. It is necessary to introduce systemic routes of siRNA delivery to treat most cancers. As mentioned above, the design criteria of an in vivo, systemic siRNA delivery system should include biocompatibility, biodegradability, and non-immunogenicity ...Author: Cong-fei Xu, Jun Wang
https://www.frontiersin.org/articles/10.3389/fphys.2016.00553/full
Nov 17, 2016 · In this review, we explore essential implications and possibilities to increase RNAi efficiency by delivery of dsRNA through non-transformative methods. We discuss factors influencing the RNAi mechanism in insects and systemic properties of dsRNA.Author: Mallikarjuna R. Joga, Moises J. Zotti, Guy Smagghe, Olivier Christiaens
https://www.pnas.org/content/113/28/7750
Jul 12, 2016 · However, suboptimal systemic delivery of RNAi agents to tumors and variable therapeutic responses because of tumor heterogeneity represent challenging hurdles to widespread clinical use. We describe an innovative near-infrared nanoplatform for systemic delivery of siRNA to ATC and real-time tracking of tumor accumulation.Author: Yanlan Liu, Viswanath Gunda, Xi Zhu, Xiaoding Xu, Jun Wu, Diana Askhatova, Omid C. Farokhzad, Sareh ...
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