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https://rnaitherapeutics.blogspot.com/
Mar 19, 2020 · When the discovery of RNAi was rewarded with the Nobel Prize in 2006, the Andy Fire and Craig Mello hammered home a message that would resonate for the years to come: to make RNAi Therapeutics, it’s all about the delivery!
https://www.nature.com/articles/s41573-019-0017-4
Mar 07, 2019 · The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all human cells. Small double-stranded RNA molecules can …Author: Ryan L. Setten, Ryan L. Setten, John J. Rossi, John J. Rossi, Si-ping Han, Si-ping Han
https://www.researchgate.net/publication/5466769_RNAi_therapeutics_An_update_on_delivery
RNAi therapeutics: An update on delivery. ... However, in vivo delivery of RNAi therapeutics is restricted because of charge density, molecular weight, and instability in the presence of nucleases ...
https://www.alnylam.com/wp-content/uploads/2018/06/RNAi-Roundtable_Platform_Slides_FINAL06262018.pdf
Platform Advances in RNAi Therapeutics • Advances in ESC+ Design for Improved Specificity and Therapeutic Index • Mark Schlegel, Ph.D., Senior Scientist, Research • New Frontiers: CNS Delivery Update • Kirk Brown, Ph.D., Associate Director, Bioanalytical Sciences Q&A Session • Moderated by Vasant Jadhav, Ph.D., Senior Director ...
https://investors.alnylam.com/press-release?id=24656
Vir and Alnylam Expand Collaboration to Advance RNAi Therapeutics for the Treatment of Coronavirus Infection, Including COVID-19. Mar 04, 2020 — Recent Alnylam advances in lung delivery technology suggest possible utility of siRNAs in targeting SARS-CoV-2 and other coronaviruses — Vir to lead development of potential coronavirus RNAi therapeutic candidates, with Alnylam retaining an option ...
https://www.alnylam.com/wp-content/uploads/2018/05/TIDES_Capella-Slides_FINAL05082018.pdf
Delivering on RNAi Therapeutics: Patisiran and Beyond. 2 ... discover and develop novel drug candidates and delivery approaches and successfully demonstrate the efficacy and safety of our product candidates; pre-clinical and clinical results for ... to update such statements.
https://rnaitherapeutics.blogspot.com/2020/03/rnai-therapeutics-and-mrna-vaccines-for.html
Mar 15, 2020 · Other RNAi-related companies with experience in inhaled lung delivery are miRNA Therapeutics company Miragen (miRNAs are structurally quite similar to RNAi triggers), Genevant/Arbutus (descendants of Tekmira which became famous for …Author: Dirk Haussecker
https://www.businesswire.com/news/home/20200304005363/en/%C2%A0Vir-Alnylam-Expand-Collaboration-Advance-RNAi-Therapeutics
Vir and Alnylam Expand Collaboration to Advance RNAi Therapeutics for the Treatment of Coronavirus Infection, Including COVID-19 — Recent Alnylam advances in lung delivery technology suggest ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978219/
Mar 30, 2007 · The use of RNAi for cancer therapeutics could revolutionize treatment of this devastating disease. The challenges for cancer are not dissimilar to those faced for other diseases, and include finding good targets, delivery and minimizing toxicity. Many oncologic targets have been reported in the literature, far too many to summarize here.Author: Lars Aagaard, John J. Rossi
https://www.ncbi.nlm.nih.gov/pubmed/25111131
Dec 10, 2014 · This presentation provides an update on the current state of RNAi therapeutics development with a particular focus on what RNAi delivery can achieve today and key challenges to be overcome to expand therapeutic opportunities.Author: D. Haussecker
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