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https://www.ncbi.nlm.nih.gov/pubmed/29243000
Over the past decade, great efforts have been undertaken to develop RNAi delivery systems that overcome these obstacles. This review presents an update on current progress in the therapeutic application of RNAi with a focus on cancer therapy and strategies for optimizing delivery systems, such as lipid-based nanoparticles. PMCID: PMC5898634 PMID:Author: Xiuhui Chen, Xiuhui Chen, Lingegowda S. Mangala, Cristian Rodriguez-Aguayo, Xianchao Kong, Gabriel L...
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-017-0683-y
Jul 28, 2017 · This review presents an overview of the mechanisms of RNAi molecules in gene therapy and the different nanoparticles used to deliver RNAi molecules; briefly describes the current uses of RNAi in cancer therapy along with the nano-based delivery of RNA molecules in previous studies; and highlights some other carriers that have been applied in ...Author: Yong Xin, Min Huang, Wen Wen Guo, Qian Huang, Long zhen Zhang, Guan Jiang
https://www.sciencedirect.com/science/article/pii/S1818087614000646
The currently developed siRNA delivery systems for cancer therapy can be divided into four categories: chemical modifications, lipid-based nanovectors, polymer-mediated delivery systems, conjugate delivery systems, and others (exosomes, RNAi-microsponges, oligonucleotide nanoparticles). 4.1. Chemical modifications of anti-cancer siRNAAuthor: Cong-fei Xu, Jun Wang
http://rnai.technology/rnai-type/top-rani-gene-therapy-companies/
Top RNAi and gene therapy companies, ddRNAi, DNA vaccines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Posttranscriptional gene silencing by RNAi represents a promising new gene therapy approach. The development of carriers, e.g., polymers, lipids, and conjugates, will be critical for the systemic delivery of siRNA therapeutics.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.researchgate.net/publication/336161535_Rekindling_RNAi_Therapy_Materials_Design_Requirements_for_In_Vivo_siRNA_Delivery
Realization of RNAi therapy requires the delivery vehicle to over-come the aforementioned extracellular barriers by either local . administration or controlled homing to the target site. For tumor
https://www.pbs.org/wgbh/nova/article/rnai-cure/
Jul 01, 2005 · The first RNAi therapy to reach patients in clinical trials is a treatment that aims at a debilitating eye disease called macular degeneration. ... Local delivery also makes it less likely that ...
https://www.nature.com/articles/d41586-019-03071-9
Oct 16, 2019 · Delivery has been such a significant challenge that those working in the area of RNAi therapeutics might be forgiven for admitting defeat. And there’s …Author: Bianca Nogrady
https://www.intechopen.com/books/gene-therapy-developments-and-future-perspectives/gene-therapy-using-rnai
Thus, gene therapy using RNAi should be effective in ablating protein function since mRNA is the template for the translation of multiple proteins. Much of the interest in RNAi is based on the fact that the RNAi mechanism operates upstream of protein production by eliminating the mRNAs coding for such proteins. ... The RNAi delivery strategies ...Author: Yu-Lin Yang, Wen Teng Chang, Yuan-Wei Shih
https://stm.sciencemag.org/content/6/240/240ps7.full
Jun 11, 2014 · RNA interference (RNAi) therapy is a rapidly emerging platform for personalized cancer treatment. Recent advances in small interfering RNA delivery and target selection provide unprecedented opportunities for clinical translation. Here, we discuss these advances and present strategies for making RNAi-based therapy a viable part of cancer management.Author: Sherry Y. Wu, Gabriel Lopez-Berestein, George A. Calin, Anil K. Sood
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