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https://www.sciencedirect.com/topics/chemistry/micellar-drug
Nanoplatin® (NC-6004) is a cisplatin-incorporated micelle that is in phase II clinical trials in patients with advanced solid tumors. In this case, the drug is incorporated into the micelle by coordination to carboxylic groups in the polyglutamic acid core ( Figure 13.49 ).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201237/
Micelles have been widely used as drug delivery carriers for a series of different molecules, including low molecular mass hydrophobic drugs, proteins, and genes [18–22]. Compared with other drug delivery strategies, micelles have two unmatched advantages. The first is their relatively small size.Author: Yang Lu, Ershuai Zhang, Jianhai Yang, Zhiqiang Cao
https://pubs.rsc.org/en/content/articlelanding/2020/py/d0py00082e
The resulting drug-loaded micelles exhibit tunable drug loading capacity and excellent long-term drug-entrapment stability due to the strong affinity between the drug and micelle core, which led to highly efficient drug loading.Author: Chih-Chia Cheng, Ya-Ting Sun, Ai-Wei Lee, Shan-You Huang, Wen-Lu Fan, Yu-Hsuan Chiao, Chih-Wei Chiu,...
http://www.authorstream.com/Presentation/Omarmarwa-1404778-micelle-drug-delivery/
Apr 30, 2012 · APPLICATIONS Micelle increases bioavailability of poorly soluble drugs. Polymeric micelle is used to target the tumor site by passive as well as active mechanism. Micelle is used in ophthalmic drug delivery system, that effectively delivers the drug to posterior tissue of eyeball. Micelle is used to encapsulate the antibiotic & anticancer drugs.
https://www.sciencedirect.com/topics/materials-science/micelle
Micelles are used for targeted drug delivery due to their high drug loading capacity, and opsonization of these micelles with sugar or peptide can also result in receptor-mediated targeted drug or gene delivery. pH and temperature-sensitive copolymers are used to develop intelligent vehicles, which are currently being used for achieving controlled release (Mourya et al., 2011). Intermolecular interaction among the block polymers leads to the formation of micelles…
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