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https://www.onlinelibrary.wiley.com/doi/pdf/10.1002/anie.200901452
Aug 12, 2009 · Aptamer advantages: Cell‐specific delivery of the anticancer drug cisplatin through a nucleolin‐aptamer‐conjugated, cisplatin‐encapsulating liposome delivery system is described.Calcein was incorporated into the target MCF‐7 cells (see top image) but not into LNCaP cells (see bottom image). More importantly, the extent of delivery can be controlled by using a complementary DNA of the ...Author: Zehui Cao, Rong Tong, Abhijit Mishra, Weichen Xu, Gerard C. L. Wong, Jianjun Cheng, Yi Lu
https://www.researchgate.net/publication/26687122_Reversible_Cell-Specific_Drug_Delivery_with_Aptamer-Functionalized_Liposomes
Cao et al. [27] also recently reported cell specific drug delivery based on aptamer functionalized liposomes. In conclusion, aptamers possess several advantages as specific targeted molecules when ...
http://wonglab.seas.ucla.edu/pdf/2009%20Angew%20Chem%20Int%20Ed%20Engl%20[Cao,%20Lu]%20Reversible%20cell-specific%20drug%20delivery%20with%20aptamer-functionalized%20liposomes.pdf
Drug Delivery DOI: 10.1002/anie.200901452 Reversible Cell-Specific Drug Delivery with Aptamer-Functionalized Liposomes** Zehui Cao, Rong Tong, Abhijit Mishra, Weichen Xu, Gerard C. L. Wong,* Jianjun Cheng,* and Yi Lu* cis-Diamminedichloroplatinum(II) (cisplatin) is a potent chemotherapeutic agent for the treatment of a broad range of cancerous ...
https://www.internetchemistry.com/news/2009/aug09/aptamer-functionalized-liposomes.php
University of Illinois researchers report that they have assembled a new cancer drug delivery system that, in cell culture, achieves all of the above. The findings appeared in the journal Angewandte Chemie [see below]. The team began with the knowledge that small, membrane-bound compartments, called liposomes, are useful as drug-delivery vehicles.
http://europepmc.org/abstract/MED/19623590
Jan 01, 2009 · Reversible cell-specific drug delivery with aptamer-functionalized liposomes. (PMID:19623590) Abstract Citations; Related Articles; Data; BioEntities; External Links ' ' Cao Z, Tong R, Mishra A, ' ' Xu W, ' ' Wong GC, ' ' Cheng J, Lu Y Angewandte Chemie ...Author: Zehui Cao, Rong Tong, Abhijit Mishra, Weichen Xu, Gerard C. L. Wong, Jianjun Cheng, Yi Lu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043981/
Oct 30, 2010 · Most recent work from the Tan lab has provided an aptamer-modified liposome system for exploiting an anti-PTK7 aptamer as a promising drug delivery vehicle (Kang et al., 2010). In this example, the sgc8 aptamer was chemically linked to the liposome by a PEG spacer, resulting in enhanced stability compared with plain liposomes.Author: Jiehua Zhou, John J. Rossi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218254/
Cao ZH, et al. Reversible Cell-Specific Drug Delivery with Aptamer- Functionalized Liposomes. Angewandte Chemie-International Edition. 2009; 48 (35):6494–6498. 43. Shangguan DH, et al. Identification of liver cancer-specific aptamers using whole live cells. ...Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.deepdyve.com/lp/wiley/reversible-cell-specific-drug-delivery-with-aptamer-functionalized-2hx06S3Ui0
Aug 17, 2009 · Reversible Cell‐Specific Drug Delivery with Aptamer‐Functionalized Liposomes Reversible Cell‐Specific Drug Delivery with Aptamer‐Functionalized Liposomes Cao, Zehui; Tong, Rong; Mishra, Abhijit; Xu, Weichen; Wong, Gerard C. L.; Cheng, Jianjun; Lu, Yi 2009-08-17 00:00:00 Aptamer advantages: Cell‐specific delivery of the anticancer drug cisplatin through a nucleolin‐aptamer ...
https://www.basepairbio.com/aptamers-vs-antibodies/
A k ey feature of monoclonal antibodies and aptamers is binding to a specific epitope, or region, on a target of interest. Specific epitope binding typically enables specific target detection. Cross-reactivity occurs when an epitope is conserved between two, typically related, targets. Species cross-reactivity occurs when an epitope is conserved between species, such as human and mouse or ...
https://www.sciencedirect.com/science/article/pii/S0168365914007160
Dec 28, 2014 · Surface modification of nanosized carriers such as liposomes, micelles, and polymeric nanoparticles with cancer cell-specific antibodies (Abs) is a common way of identifying cancer cell-surface targets , , , which then uptake the Abs-conjugated …Author: Si Eun Baek, Kwang Hyun Lee, Yong Serk Park, Deok-Kun Oh, Sangtaek Oh, Keun-Sik Kim, Dong-Eun Kim
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