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https://www.onlinelibrary.wiley.com/doi/pdf/10.1002/anie.200901452
Aug 12, 2009 · Aptamer advantages: Cell‐specific delivery of the anticancer drug cisplatin through a nucleolin‐aptamer‐conjugated, cisplatin‐encapsulating liposome delivery system is described. Calcein was incorporated into the target MCF‐7 cells (see top image) but …Author: Zehui Cao, Rong Tong, Abhijit Mishra, Weichen Xu, Gerard C. L. Wong, Jianjun Cheng, Yi Lu
https://www.researchgate.net/publication/26687122_Reversible_Cell-Specific_Drug_Delivery_with_Aptamer-Functionalized_Liposomes
Cao et al. [27] also recently reported cell specific drug delivery based on aptamer functionalized liposomes. In conclusion, aptamers possess several advantages as specific targeted molecules when ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043981/
Oct 30, 2010 · In 2009, Cao et al. developed a reversible AS1411 aptamer–liposome bioconjugate that can effectively deliver cisplatin in a cancer-cell-specific manner (Cao et al., 2009). The 3′-terminal cholesterol tag of the aptamer ensures immobilization of aptamers on the liposome surface by insertion into the hydrophobic lipid membrane.Author: Jiehua Zhou, John J. Rossi
http://wonglab.seas.ucla.edu/pdf/2009%20Angew%20Chem%20Int%20Ed%20Engl%20[Cao,%20Lu]%20Reversible%20cell-specific%20drug%20delivery%20with%20aptamer-functionalized%20liposomes.pdf
Drug Delivery DOI: 10.1002/anie.200901452 Reversible Cell-Specific Drug Delivery with Aptamer-Functionalized Liposomes** Zehui Cao, Rong Tong, Abhijit Mishra, Weichen Xu, Gerard C. L. Wong,* Jianjun Cheng,* and
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218254/
The cell membrane is basically a dynamic lipid bilayer; therefore, this liposome nanostructure can efficiently increase cell permeability and enhance drug delivery. A cell-permeable sgc8-PEG-liposome nanostructure has also been reported for drug delivery . With approximately 250 aptamers on each liposome, this design leads to multiple aptamer ...Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.deepdyve.com/lp/wiley/reversible-cell-specific-drug-delivery-with-aptamer-functionalized-2hx06S3Ui0
Aug 17, 2009 · Read "Reversible Cell‐Specific Drug Delivery with Aptamer‐Functionalized Liposomes, Angewandte Chemie International Edition" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.internetchemistry.com/news/2009/aug09/aptamer-functionalized-liposomes.php
The drug must also spare healthy cells, and - ideally - its effects will be reversible, to cut short any potentially dangerous side effects. University of Illinois researchers report that they have assembled a new cancer drug delivery system that, in cell culture, achieves all of the above.
http://europepmc.org/abstract/MED/19623590
Jan 01, 2009 · Author: Cao Z, Journal: Angewandte Chemie (International ed. in English)[2009]Author: Zehui Cao, Rong Tong, Abhijit Mishra, Weichen Xu, Gerard C. L. Wong, Jianjun Cheng, Yi Lu
https://www.sciencedirect.com/science/article/pii/S2162253116303092
The two main strategies for targeted delivery using cell-specific aptamers are: (i) aptamer-drug conjugates, in which aptamer is directly conjugated to the drug molecules via either a connector or a physical intercalation, and (ii) the aptamer-nanomaterials system, in which the aptamer is decorated on the surface of nanocarriers for targeted ...Author: Jiehua Zhou, John J. Rossi
https://www.basepairbio.com/aptamers-vs-antibodies/
One drawback to the use of antibodies in therapeutics is immunogenicity – generation of an immune response to the antibody drug and production of anti-drug antibodies. Anti-drug antibodies (ADA) can induce unwanted reactions, alter drug pharmacokinetics, or reduce treatment efficacy by …
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