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https://www.slideshare.net/VARSHAAWASAR/brain-targeted-drug-delivery-system
Aug 04, 2014 · Brain targeted drug delivery system 1. Presented By, Varsha V. Awasarkar M Pharm 2nd Semister, (Pharmaceutics) Under the guidance of, Dr. K. H. Ramteke (Department of Pharmaceutics) 1 AWASARKAR VARSHA V.
https://www.slideshare.net/ShashankSoni/brain-targeted-drug-delivery
Mar 23, 2017 · Brain Targeted Drug Delivery 1. APPROACH TO TARGET BRAIN DRUG DELIVERY SYSTEM SCHOLAR: MANISH KUMAR M.Pharm (Pharmaceutics) GUIDED BY: Mr. SHASHANK SONI Assistant Professor SARDAR BHAGWAN SINGH P.G. INSTITUTE OF BIO-MEDICAL SCIENCES & RESEARCH, BALAWALA, DEHRADUN, (UTTARAKHAND)
https://pubs.acs.org/doi/full/10.1021/jm00357a002
Effects of A Brain-Enhanced Chemical Delivery System for Estradiol on Body Weight and Serum Hormones in Middle-Aged Male Rats. Endocrine Research 1988, 14 (2-3) , 131-148. DOI: 10.3109/07435808809032982. NICHOLAS BODOR. Redox Drug Delivery Systems for Targeting Drugs to …Author: Nicholas Bodor, Hassan H. Farag
https://www.ncbi.nlm.nih.gov/pubmed/6827552
Improved delivery through biological membranes. 11. A redox chemical drug-delivery system and its use for brain-specific delivery of phenylethylamine. Bodor N, Farag HH. A dihydropyridine in equilibrium pyridinium salt type redox system is described as a general and flexible method for site-specific and sustained delivery of drugs to the brain.Author: Nicholas Bodor, Hassan H. Farag
https://www.sciencedirect.com/science/article/pii/0169409X94900426
2. Application of the redox-based chemical delivery system (CDS) technology to brain-directed dopamine delivery The BBB is a unique complex of morphological arrangements of endothelial cells and glia and of related enzyme components, which effectively ex- cludes blood-borne substances from the brain [9 11].Author: James W. Simpkins, Nicholas Bodor
https://onlinelibrary.wiley.com/doi/abs/10.1002/1098-1128%28200009%2920%3A5%3C367%3A%3AAID-MED3%3E3.0.CO%3B2-P
Abstract Chemical delivery systems (CDSs) based on the redox conversion ... ‐insoluble pyridinium salt have been developed to improve the access of therapeutic agents to the central nervous system. A dihydropyridinium‐type CDS or a redox analog of the drug is sufficiently lipophilic to enter the brain by passive transport, then undergoes an ...Author: Laszlo Prokai, Katalin Prokai-Tatrai, Nicholas Bodor
https://www.researchgate.net/publication/227886755_Targeting_Drugs_to_the_Brain_by_Redox_Chemical_Delivery_Systems
The objective of the present study is to investigate the redox drug delivery system for the delivery of bis(2-chloroethyl)amine (nor mustard) as alkylating cytotoxic agent to the brain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC284548/
Abstract. Enhanced delivery of ganciclovir to the brain was demonstrated by a redox-based chemical delivery system. A ganciclovir monoester in which a 1-methyl-1,4-dihydronicotinate was covalently attached to one of the hydroxymethyl functions was prepared.Author: M E Brewster, K Raghavan, E Pop, N Bodor
https://www.sciencedirect.com/science/article/pii/S187853521300436X
One of the most promising approaches for brain delivery is the prodrug concept of brain-specific chemical drug delivery system (CDS) based on redox system analogous to the endogenous NADH ↔ NAD + coenzyme system developed by Bodor et al. (1981). According to this, polar drug linked to a lipophilic 1,4-dihydropyridine carrier could easily ...Author: Rajesh K. Singh, D.N. Prasad, T.R. Bhardwaj
https://patents.google.com/patent/US5017566A/en
Inclusion complexes of hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of β- and γ-cyclodextrin with the reduced, biooxidizable, blood-brain barrier penetrating, lipoidal forms of dihydropyridine⃡pyridinium salt redox systems for brain-targeted drug delivery provide a means for stabilizing the redox systems, particularly against oxidation.Author: Nicholas S. Bodor
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