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https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-018-0398-2
Sep 22, 2018 · Redox-responsive drug delivery systems have been recognized as a valuable strategy to achieve efficient intracellular drug delivery with low cytotoxicity. Utilizing the differences between the special microenvironments of tumor cells and normal cells, redox-responsive delivery systems can meet the requirement of targeted therapy in theory.Author: Xiaoshuang Guo, Yuan Cheng, Xiaotian Zhao, Yanli Luo, Jianjun Chen, Wei-En Yuan
https://www.sciencedirect.com/science/article/pii/S1818087619301199
Redox responsive drug delivery systems (DDSs) are developed based on the high level of GSH in tumor cells. However, there are also GSH in normal cell though its level is lower. In order to control the release of drugs more accurately and reduce side effects, other drug release stimuli have been introduced to redox responsive DDSs.Author: Ruirui Li, Feifei Peng, Jia Cai, Dandan Yang, Peng Zhang
https://onlinelibrary.wiley.com/doi/10.1002/adhm.201900406
Jun 11, 2019 · Rational design of controllable drug release systems is important for tumor treatments due to the nonspecific toxicity of many chemotherapeutics. Herein, laser or light responsive pharmaceutical delivery nanoparticles are designed, by taking the advantages of redox responsive selenium (Se) substituted polymer as shell and photosensitive porphyrin zirconium metal–organic frameworks (MOF) …Author: Zheng Luo, Lu Jiang, Shaoxiong Yang, Zibiao Li, Wee Mia Wilson Soh, Liyan Zheng, Xian Jun Loh, Yun‐L...
https://www.mdpi.com/1996-1944/13/6/1279
In order to achieve a controlled release drug delivery system (DDS) for cancer therapy, a pH and redox dual-responsive mesoporous silica nanoparticles (MSN)-sulfur (S)-S- chitosan (CS) DDS was prepared via an amide reaction of dithiodipropionic acid with amino groups on the surface of MSN and amino groups on the surface of CS.Author: Yanqin Xu, Liyue Xiao, Yating Chang, Yuan Cao, Changguo Chen, Dan Wang
https://www.ncbi.nlm.nih.gov/pubmed/30243297
Sep 22, 2018 · Moreover, redox-responsive delivery systems are often applied to significantly improve drug concentrations in targeted cells, increase the therapeutic efficiency and reduce side effects or toxicity of primary drugs.Author: Xiaoshuang Guo, Yuan Cheng, Xiaotian Zhao, Yanli Luo, Jianjun Chen, Wei-En Yuan
https://jnanobiotechnology.biomedcentral.com/track/pdf/10.1186/s12951-018-0398-2
Advances in redox-responsive drug delivery systems of tumor microenvironment Xiaoshuang Guo 1 ,Yuan Cheng 1 ,Xiaotian Zhao 1 ,Yanli Luo 2 ,Jianjun Chen 3* and Wei‑En Yuan 1*Author: Xiaoshuang Guo, Yuan Cheng, Xiaotian Zhao, Yanli Luo, Jianjun Chen, Wei-En Yuan
https://www.sciencedirect.com/science/article/abs/pii/S0168365919300343
Redox responsive and pH responsive dual release mechanism synergistically accelerating drug release in cancer cells. Long circulation time and gradually accumulation in tumor sites (> 48 h). Significant inhibition of tumor growth without observed side effects.Author: Ying Qu, Bingyang Chu, Xiawei Wei, Minyi Lei, Danrong Hu, Ruoyu Zha, Lin Zhong, Mengyao Wang, Fangfa...
https://www.sciencedirect.com/science/article/pii/S1773224720300381
Apr 07, 2020 · Tumor cell internalization and controlling drug release are two major biological barriers, which limit the clinical application of chemotherapeutic dr…
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