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https://onlinelibrary.wiley.com/doi/abs/10.1002/1098-1128%28200009%2920%3A5%3C367%3A%3AAID-MED3%3E3.0.CO%3B2-P
A dihydropyridinium‐type CDS or a redox analog of the drug is sufficiently lipophilic to enter the brain by passive transport, then undergoes an enzymatic oxidation to an ionic pyridinium compound, which promotes retention in the CNS.Author: Laszlo Prokai, Katalin Prokai-Tatrai, Nicholas Bodor
https://www.researchgate.net/publication/227886755_Targeting_Drugs_to_the_Brain_by_Redox_Chemical_Delivery_Systems
The objective of the present study is to investigate the redox drug delivery system for the delivery of bis(2-chloroethyl)amine (nor mustard) as alkylating cytotoxic agent to the brain.
http://europepmc.org/abstract/MED/2894793
Redox-responsive nano-carriers as tumor-targeted drug delivery systems. Raza A , Hayat U , Rasheed T , Bilal M , Iqbal HMN Eur J Med Chem , 157:705-715, 13 Aug 2018
https://www.sciencedirect.com/science/article/pii/S1818087619301199
Redox responsive drug delivery systems (DDSs) are developed based on the high level of GSH in tumor cells. However, there are also GSH in normal cell though its level is lower. In order to control the release of drugs more accurately and reduce side effects, other drug release stimuli have been introduced to redox responsive DDSs.Author: Ruirui Li, Feifei Peng, Jia Cai, Dandan Yang, Peng Zhang
https://www.sciencedirect.com/science/article/pii/0169409X94900426
Application of the redox-based chemical delivery system (CDS) technology to brain-directed dopamine delivery The BBB is a unique complex of morphological arrangements of endothelial cells and glia and of related enzyme components, which effectively ex- cludes blood-borne substances from the brain …Author: James W. Simpkins, Nicholas Bodor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC284548/
Enhanced delivery of ganciclovir to the brain was demonstrated by a redox-based chemical delivery system. A ganciclovir monoester in which a 1-methyl-1,4-dihydronicotinate was covalently attached to one of the hydroxymethyl functions was prepared.Author: M E Brewster, K Raghavan, E Pop, N Bodor
https://pubs.acs.org/doi/full/10.1021/jm00357a002
Effects of A Brain-Enhanced Chemical Delivery System for Estradiol on Body Weight and Serum Hormones in Middle-Aged Male Rats. Endocrine Research 1988, 14 (2-3) , 131-148. DOI: 10.3109/07435808809032982. NICHOLAS BODOR. Redox Drug Delivery Systems for Targeting Drugs to the Brain.Author: Nicholas Bodor, Hassan H. Farag
https://www.researchgate.net/publication/279408805_Brain_targeting_Drug_Delivery_System_A_Review
In order to distribute the drugs into the CNS via passing the blood brain barrier, many new emerging approaches have been developed for example Magnetic drug targeting, chemical delivery Systems, Drug carrier systems (antibodies, liposomes or Nanoparticles).
https://www.slideshare.net/VARSHAAWASAR/brain-targeted-drug-delivery-system
Aug 04, 2014 · • Among the three main approaches to drug delivery to the CNS - systemic administration, injection into CSF pathways, and direct injection into the brain, the greatest developments is anticipated to occur in the area of targeted delivery by systemic administration.
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