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http://ijpsr.com/bft-article/liver-specific-drug-targeting-strategies-a-review/?view=fulltext
Liver targeting: The liver is a critical target tissue for drug delivery because many fatal conditions including chronic hepatitis, enzyme deficiency, and hepatoma occur in hepatocytes. In general, liver targeting systems employ passive trapping of microparticles by reticuloendothelium or active targeting based on recognition between hepatic receptor and ligand-bearing particulates 36 .
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273112/
Sep 16, 2014 · Liver biology, innovative drugs, and arising hope from nanomedicine. The liver is the largest internal human organ weighing about 1.5 kg in an adult, with many essential roles in metabolism and clearance. Bile acids are formed by the liver, which are of critical importance for the maintenance of cholesterol metabolism and intestinal lipid absorption.Author: Matthias Bartneck, Klaudia Theresa Warzecha, Frank Tacke
https://link.springer.com/chapter/10.1007%2F978-0-387-49785-3_16
Drugs for treating liver diseases are often limited by tolerability and extra-hepatic safety concerns, which prevent their use at maximally effective doses. Targeting drugs to the liver may circumvent some of these limitations and enable more effective therapies.Author: Mark D. Erion
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826320/
Oct 28, 2013 · 2. Morphological Study of Liver . Before discussing the different methods of targeting, it is necessary to understand the morphology of liver (especially vascular supply) and molecular scale of the target tissue in order to design a novel drug delivery system rationally.Author: Nidhi Mishra, Narayan Prasad Yadav, Vineet Kumar Rai, Priyam Sinha, Kuldeep Singh Yadav, Sanyog Jain...
https://www.researchgate.net/publication/8372583_Liver-Targeted_Drug_Delivery_Using_HepDirect_Prodrugs
This chapter reviews the liver-targeting strategies explored to date and, more specifically, the strengths and weaknesses of various prodrug strategies used for liver-specific drug delivery. View ...
http://www.authorstream.com/Presentation/munugoti.suman86-1134578-liver-targetting/
Aug 04, 2011 · SELECTIVE DRUG DELIVERY FOR THE TREATMENT OF OTHER HEPATIC DISORDERS Drug targeting preparations have been given to patients with various infectious diseases. For the treatment of Leishmaniasis , liposomes as well as mannosylated HSA have been used to deliver antiparasitic drugs, such as methotrexate , amphotericin B, doxorubicin and muramyl dipeptide to KCs.
https://www.researchgate.net/publication/260643363_Recent_Advances_in_Active_Hepatic_Targeting_Drug_Delivery_System
Hepatic diseases are turning into one of the few diseases that cannot be effectively cured due to some reasons although various receptors existed in the liver. Currently, several passive targeting delivery systems have been used in the drug/gene delivery for the treatment of hepatic diseases.
http://www.eurekaselect.com/146516/article
Therapy of Chronic Hepatitis C in the Era of Nanotechnology: Drug Delivery Systems and Liver Targeting Author(s): Maria Lujan Cuestas . Institute of Microbiology and Medical Parasitology, University of Buenos Aires-National Science Research Council (IMPaM, UBA-CONICET), Ciudad Autonoma de Buenos Aires,, ArgentinaAuthor: Maria Lujan Cuestas
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/targeted-drug-delivery
Targeted drug delivery (TDD) is emerging as a powerful tool for the treatment of cancer because of enhanced delivery of drugs, as well as genes, to a tumor …
https://www.hindawi.com/journals/bmri/2013/382184/
Later on, Shi et al. constructed a liposomal liver targeting delivery system by adding soybean-derived sterylglucoside (SG) to the cationic liposomes and concluded that SG/Brij-35 modified cationic liposomes are potentially useful drug carrier to the liver.Author: Nidhi Mishra, Narayan Prasad Yadav, Vineet Kumar Rai, Priyam Sinha, Kuldeep Singh Yadav, Sanyog Jain...
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