We have collected information about Liver Targeting Drug Delivery for you. Follow the links to find out details on Liver Targeting Drug Delivery.
http://ijpsr.com/bft-article/liver-specific-drug-targeting-strategies-a-review/?view=fulltext
Liver targeting: The liver is a critical target tissue for drug delivery because many fatal conditions including chronic hepatitis, enzyme deficiency, and hepatoma occur in hepatocytes. In general, liver targeting systems employ passive trapping of microparticles by reticuloendothelium or active targeting based on recognition between hepatic receptor and ligand-bearing particulates 36 .
https://link.springer.com/chapter/10.1007%2F978-0-387-49785-3_16
Drugs for treating liver diseases are often limited by tolerability and extra-hepatic safety concerns, which prevent their use at maximally effective doses. Targeting drugs to the liver may circumvent some of these limitations and enable more effective therapies.Author: Mark D. Erion
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273112/
Sep 16, 2014 · Therefore, using viral pathways of cell entry by masking nanoparticles may be useful for a cell specific targeting in liver or other organs, which should be used to decorate particles intended for the delivery of drugs to liver cells.Author: Matthias Bartneck, Klaudia Theresa Warzecha, Frank Tacke
http://jpet.aspetjournals.org/content/312/2/554
Feb 01, 2005 · Here we show that a series of phosphate and phosphonate prodrugs, called HepDirect prodrugs, results in liver-targeted drug delivery following a cytochrome P450-catalyzed oxidative cleavage reaction inside hepatocytes.Author: Mark D. Erion, Paul D. van Poelje, Deidre A. MacKenna, Timothy J. Colby, Annika C. Montag, James M. ...
https://www.researchgate.net/publication/8372583_Liver-Targeted_Drug_Delivery_Using_HepDirect_Prodrugs
Here we show that a series of phosphate and phosphonate prodrugs, called HepDirect prodrugs, results in liver-targeted drug delivery following a cytochrome P450-catalyzed oxidative cleavage...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826320/
Oct 28, 2013 · Normally most of the drugs achieve high hepatic concentration, still their targeting is necessary because liver is the major organ in the body equipped for uptake, detoxification, metabolic transformation, and excretion of xenobiotics into bile by means of carrier-mediated mechanism.Author: Nidhi Mishra, Narayan Prasad Yadav, Vineet Kumar Rai, Priyam Sinha, Kuldeep Singh Yadav, Sanyog Jain...
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