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https://www.sciencedirect.com/science/article/pii/B9780123849359100021
2.3. Stability of Proteins and Peptides in Pulmonary Delivery Formulations. The biological activity of proteins is strongly dependent on their molecular structure, which involves several organization levels .The primary structure is the amino acid sequence, which ultimately dictates the non-covalent interactions that the molecule undergoes when forming higher order structures.Author: Philip Chi Lip Kwok, Hak-Kim Chan
https://www.sciencedirect.com/science/article/pii/S0939641112000392
The aim of this study was to prepare novel Zn 2+-cross-linked alginate microparticles for controlled pulmonary delivery of protein drugs via a simple one-step spray-drying process and to physicochemically characterize these systems.Microparticles were prepared by spray-drying aqueous alginate solutions, containing the model protein BSA, Zn(NH 3) 4 SO 4, and optionally additional excipients.Author: Katrin Möbus, Jürgen Siepmann, Roland Bodmeier
https://www.ondrugdelivery.com/pulmonary-delivery-antimicrobial-peptides/
nanocarriers for pulmonary delivery of peptides Figure 2: Schematic illustration of the possible action mechanisms of antimicrobial peptides interacting with cell membranes. 13 As soon as they enter the body, AMPs, as well as other peptides and proteins, are attacked by proteases, which break them down into amino acids and shorter fragments.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276033/
This method has been used in the pharmaceutical field for production of microparticles, nanoparticles, liposomes, and inclusion complexes. This method is used for the production of particulate pulmonary drug delivery systems containing proteins and peptides, and also used to improve the formulation properties of certain drug candidates.[37,38]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59577/
Apr 12, 2001 · The large surface area, good vascularization, immense capacity for solute exchange and ultra-thinness of the alveolar epithelium are unique features of the lung that can facilitate systemic delivery via pulmonary administration of peptides and proteins.Author: Remigius Uchenna Agu, Michael Ikechukwu Ugwoke, Michoel Armand, Renaat Kinget, Norbert Verbeke
https://www.researchgate.net/publication/277306217_Pulmonary_Delivery_of_Peptides_and_Proteins
Active research is being carried out in pulmonary delivery of proteins, but so far very few respirable proteins have been marketed and practically no absorption enhancers have been approved.
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
Growing attention has been given to the potential of a pulmonary route as an non-invasive administration for systemic delivery of therapeutic agents (mainly peptides and proteins) due to the fact that the lungs provides an big surface area through which molecules can be …
https://www.researchgate.net/publication/38033709_Novel_pMDI_formulations_for_pulmonary_delivery_of_proteins
Novel pMDI formulations for pulmonary delivery of proteins Hao-Ying Li, Peter C. Seville ∗ School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
https://www.medscape.com/viewarticle/734991
Oct 26, 2019 · Owing to the physiological characteristics of the respiratory system, the pulmonary route has received special attention for protein drug delivery. Several peptides and proteins for pulmonary ...
http://www.eurekaselect.com/133583/article
Furthermore, recent patents in gene delivery to the lungs have also been discussed. List of patents included in this review is comprehensive in terms of pulmonary delivery of therapeutics. It includes inventions related to proteins and peptides, DNA therapeutics, siRNA and other genetic materials with therapeutic applications.
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