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https://www.sciencedirect.com/science/article/pii/B9780123849359100021
The fragility of proteins also demands specific packaging and storage conditions, so as to minimize the loss of biological activity. Proteins and peptides can be delivered using a variety of aerosol devices such as nebulizers, the AERx ® pulmonary delivery system, metered dose inhalers, and dry powder inhalers.Author: Philip Chi Lip Kwok, Hak-Kim Chan
https://www.sciencedirect.com/science/article/abs/pii/0168365994900817
There have been many attempts to improve systemic delivery of peptide and protein drugs by routes of administration other than by injection. Studies in this area of drug delivery have included nasal, rectal, buccal and the transdermal route of administration. There is little research in the area of pulmonary delivery of these compounds.Author: A. Adjei, P. Gupta
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59577/
Apr 12, 2001 · The mucus (1–10 μm thick) that lines the pulmonary epithelium and the surfactant that lines the alveoli (0.1–0.2 μm thick) constitute physical barriers to pulmonary absorption of peptides and proteins. They have high concentrations of protease inhibitors, and presumably protect peptides and proteins from degradation.Author: Remigius Uchenna Agu, Michael Ikechukwu Ugwoke, Michoel Armand, Renaat Kinget, Norbert Verbeke
https://www.ondrugdelivery.com/pulmonary-delivery-antimicrobial-peptides/
The peptides in FORMAMP are new, but peptides for other medical uses have been under investigation for a few decades, as the lung is a suitable route for systemic delivery without first-pass effects. The most studied peptide for pulmonary delivery is insulin, for which rapid systemic delivery is the target.
https://www.researchgate.net/publication/277306217_Pulmonary_Delivery_of_Peptides_and_Proteins
Pulmonary Delivery of Peptides and Proteins. Pulmonary delivery offers direct drug targeting for local diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. Inhalation therapy may also be applied to treating systemic diseases, as it has some advantages over other routes of administration.
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
Pulmonary delivery of drug has become an attractive target and of tremendous scientific and biomedical interest in the health care research area as the lung is capable of absorbing pharmaceuticals either for local deposition or for systemic delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276033/
Pulmonary route of drug delivery gaining much importance in the present day research field as it enables to target the drug delivery directly to lung both for local and systemic treatment. Over the last 2 decades, the systemic absorption of a broad range of therapeutics after pulmonary application has been demonstrated in animals as well as in humans.
https://www.cell.com/trends/biotechnology/pdf/S0167-7799(98)01186-X.pdf
deliver proteins and peptides, including pulmonary, oral, mucosal-membrane and transcutaneous1–12. Administration via these routes often requires delivery vehicles and/or permeability enhancers, which assist in transfer across the delivery site and into the systemic circulation. Proteins and peptides have also been deliv-
https://link.springer.com/article/10.1023/A:1018980630675
Aug 01, 1994 · Abstract. The present study investigated the feasibility of utilizing receptor-mediated endocytosis as a means to enhance peptide delivery to the pulmonary epithelium. The strategy employs a molecular conjugate consisting of a cognate moiety, transferrin (TF), covalently-linked to a model polypeptide, horseradish peroxidase (HRP),...Author: Deepa Deshpande, David Toledo-Velasquez, Li Ying Wang, Carl J. Malanga, Joseph K. H. Ma, Yongyut Roj...
http://www.eurekaselect.com/138872/article
Delivery to the lungs is an efficient way to deliver drugs directly to the site of action or to the blood circulation. Because of limitations of direct administration of free drugs, particulate drug delivery systems such as DPI formulations based on nanoparticles (NPs) have been of interest for pulmonary drug delivery.Author: Farideh Shiehzadeh, Mohsen Tafaghodi
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