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https://www.sciencedirect.com/science/article/pii/B9780123849359100021
Since pulmonary delivery is a relatively new route of administration for proteins, the long-term adverse effects of usage over decades are uncertain. However, many proteins and peptides have been shown to be generally safe for inhalation in the short-term, at least they are not more harmful than subcutaneous injections [5] .Author: Philip Chi Lip Kwok, Hak-Kim Chan
https://www.sciencedirect.com/science/article/abs/pii/0168365994900817
There have been many attempts to improve systemic delivery of peptide and protein drugs by routes of administration other than by injection. Studies in this area of drug delivery have included nasal, rectal, buccal and the transdermal route of administration. There is little research in the area of pulmonary delivery of these compounds.Author: A. Adjei, P. Gupta
https://www.sciencedirect.com/science/article/pii/0168365994900817
There have been many attempts to improve systemic delivery of peptide and protein drugs by routes of administration other than by injection. Studies in this area of drug delivery have included nasal, rectal, buccal and the transdermal route of administration. There is little research in the area of pulmonary delivery of these compounds.Author: A. Adjei, P. Gupta
https://www.researchgate.net/publication/277306217_Pulmonary_Delivery_of_Peptides_and_Proteins
Pulmonary Delivery of Peptides and Proteins. Pulmonary delivery offers direct drug targeting for local diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. Inhalation therapy may also be applied to treating systemic diseases, as it has some advantages over other routes of administration.
https://onlinelibrary.wiley.com/doi/10.1002/9783527609628.ch9
Biopharmaceutical Challenges: Pulmonary Delivery of Proteins and Peptides Kun Cheng Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center, 26 S. Dunlap Street, Memphis, TN 38163, USAAuthor: Kun Cheng, Ram I. Mahato
https://www.ncbi.nlm.nih.gov/pubmed/18204175
For this purpose, a number of biophysical and physiological parameters have to be considered, such as particle diameter, particle density, hygroscopicity, electrical charge, chemical properties of the substance and age, pulmonary diseases, breathing pattern, all of which affect the mechanisms of pulmonary drug deposition.Author: Scheuch G, Siekmeier R
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374550/
Pulmonary administration is an attractive route of proteins and peptides than other alternative routes of administration. The lungs offer a large surface area for drug absorption, of approximately 80-140 m 2 .
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59577/
Apr 12, 2001 · The mucus (1–10 μm thick) that lines the pulmonary epithelium and the surfactant that lines the alveoli (0.1–0.2 μm thick) constitute physical barriers to pulmonary absorption of peptides and proteins. They have high concentrations of protease inhibitors, and presumably protect peptides and proteins from degradation.Author: Remigius Uchenna Agu, Michael Ikechukwu Ugwoke, Michoel Armand, Renaat Kinget, Norbert Verbeke
https://www.polyplus-transfection.com/products/pulsin/
The delivery of protein and antibody using PULSin represents a powerful approach for functional studies. For example, PULSin enables you to study lethal proteins by controlling the level and time course of protein delivery into the cells.Cell types: Adherent & suspension cells grown in presence of serum
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839019/
Apr 20, 2016 · This increased binding is achieved due to the ability of proteins and peptides to change their conformation during binding to better fit the binding pocket in their receptor . This review concentrates on asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD), three respiratory diseases typified by airflow limitations and poor alveolar gas exchange.Author: Robert C. Fellner, Shawn T. Terryah, Robert Tarran
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