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https://onlinelibrary.wiley.com/doi/abs/10.1002/9780470688397.ch14
RNA Interference: Mechanism of Action. Lung Physiology. Animal Models. siRNA Delivery to Treat Pulmonary Diseases. siRNA‐Induced Inflammatory Response. Case Studies. Faster Drug for Unknown Bugs. Conclusions. References
https://www.future-science.com/doi/10.4155/tde-2019-0009?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3Dwww.ncbi.nlm.nih.gov
The primary barrier for pulmonary siRNA delivery is the extensively branched structure of the airways with variable lengths and diameters, followed by the presence of lung fluids, such as mucus and surfactant , as well as mucociliary clearance mechanisms including alveolar macrophages.Author: Rima Kandil, Olivia M Merkel
https://link.springer.com/protocol/10.1007/978-1-59745-210-6_3
RNA interference Small interfering RNA In vivo delivery RNAi therapeutics Nanoparticle Local delivery Systemic delivery. This is a preview of subscription content, log in to check access. Springer Nature is developing a new tool to find and evaluate Protocols.Author: Patrick Y. Lu, Martin C. Woodle
https://www.sciencedirect.com/science/article/pii/S0169409X11000408
Small interfering RNA (siRNA) has a huge potential for the treatment or prevention of various lung diseases. Once the RNA molecules have successfully entered the target cells, they could inhibit the expression of specific gene sequence through RNA interference (RNAi) mechanism and generate therapeutic effects.Author: Jenny Ka-Wing Lam, Wanling Liang, Hak-Kim Chan
https://www.researchgate.net/publication/5482536_Delivering_Small_Interfering_RNA_for_Novel_Therapeutics
The manifestation of RNA interference (RNAi)-based therapeutics lies in safe and successful delivery of small interfering RNAs (siRNAs), the molecular entity that triggers and guides...
https://www.researchgate.net/publication/50225388_Pulmonary_delivery_of_therapeutic_siRNA
Pulmonary delivery is a promising approach of delivering RNAi therapeutics directly to the airways for treating local conditions and minimizing systemic side effects. It is a non-invasive route of...
https://www.ncbi.nlm.nih.gov/pubmed/26148454
RNA interference (RNAi) is often thought to be the answer in the search for more efficient and biocompatible treatments. However, difficulties of efficient delivery of small interference RNA (siRNA), the key factor in RNAi, to target cells and tissues have limited its clinical application.Author: Yuran Xie, Olivia M. Merkel
https://www.sciencedirect.com/science/article/pii/S0169409X16301223
3. Pulmonary delivery of RNAi therapeutics for TB treatment. Safe and efficient delivery of RNAi molecules to their site of action is a key to the success of RNAi therapeutics. In current TB treatment, anti-TB agents are usually delivered systemically either by oral or parenteral administration.Author: Dede K.W. Man, Michael Y.T. Chow, Luca Casettari, Mercedes Gonzalez-Juarrero, Jenny K.W. Lam
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381599/
This is a highly interesting observation that promotes noninvasive pulmonary delivery as a realistic route for administration of oligonucleotide therapeutics to the liver and kidney. The lack of functional activity of naked ASO and siRNA in the lung contradicts …Author: Jørgen Kjems, Kenneth A Howard
https://cancerres.aacrjournals.org/content/70/7/2571
Apr 01, 2010 · The dynamic properties of RNA interference (RNAi) in cancer biology have led investigators to pursue with significant interest its role in tumorigenesis and cancer therapy. We recently reported that decreased expression of key RNAi enzymes, Dicer and Drosha, in epithelial ovarian cancers was associated with poor clinical outcome in patients.Author: William M. Merritt, Menashe Bar-Eli, Anil K. Sood
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