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https://www.sciencedirect.com/science/article/abs/pii/0168365994900817
There have been many attempts to improve systemic delivery of peptide and protein drugs by routes of administration other than by injection. Studies in this area of drug delivery have included nasal, rectal, buccal and the transdermal route of administration. There is little research in the area of pulmonary delivery of these compounds.Author: A. Adjei, P. Gupta
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59577/
Apr 12, 2001 · The major concern regarding pulmonary administration of therapeutic peptides and proteins via the lung is the possibility of immunological reactions, because the body may recognize these molecules as antigens.Author: Remigius Uchenna Agu, Michael Ikechukwu Ugwoke, Michoel Armand, Renaat Kinget, Norbert Verbeke
https://www.amazon.com/Inhalation-Delivery-Therapeutic-Peptides-Proteins/dp/0824797809
the systemic delivery of peptide and protein drugs using fine-particle technology gene therapy employing gene delivery through the airways new developments in pulmonary delivery technologies emphasizing inhaled peptide and protein drugsAuthor: Akwete Adjei
https://www.researchgate.net/publication/277306217_Pulmonary_Delivery_of_Peptides_and_Proteins
Pulmonary Delivery of Peptides and Proteins. Pulmonary delivery offers direct drug targeting for local diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. Inhalation therapy may also be applied to treating systemic diseases, as it has some advantages over other routes of administration.
https://www.ondrugdelivery.com/pulmonary-delivery-antimicrobial-peptides/
The peptides in FORMAMP are new, but peptides for other medical uses have been under investigation for a few decades, as the lung is a suitable route for systemic delivery without first-pass effects. The most studied peptide for pulmonary delivery is insulin, for which rapid systemic delivery is the target.
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
Growing attention has been given to the potential of a pulmonary route as an non-invasive administration for systemic delivery of therapeutic agents (mainly peptides and proteins) due to the fact that the lungs provides an big surface area through which molecules can be absorbed and goes direct into the bloodstream.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839019/
Apr 20, 2016 · Conversely, for many peptides/proteins, an inability to cross the respiratory epithelium after inhaled delivery may actually be advantageous as it would result in a high ratio of lung to systemic bioavailability and thus would reduce off-target effects .Author: Robert C. Fellner, Shawn T. Terryah, Robert Tarran
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