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https://www.sciencedirect.com/science/article/pii/B9780123849359100021
These natural defense mechanisms can inadvertently oppose therapeutic protein delivery and need to be overcome if absorption is to increase. Active research is being carried out in pulmonary delivery of proteins, but so far very few respirable proteins have been marketed and practically no absorption enhancers have been approved.Author: Philip Chi Lip Kwok, Hak-Kim Chan
https://www.sciencedirect.com/science/article/abs/pii/0168365994900817
There have been many attempts to improve systemic delivery of peptide and protein drugs by routes of administration other than by injection. Studies in this area of drug delivery have included nasal, rectal, buccal and the transdermal route of administration. There is little research in the area of pulmonary delivery of these compounds.Author: A. Adjei, P. Gupta
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59577/
Apr 12, 2001 · The large surface area, good vascularization, immense capacity for solute exchange and ultra-thinness of the alveolar epithelium are unique features of the lung that can facilitate systemic delivery via pulmonary administration of peptides and proteins.Author: Remigius Uchenna Agu, Michael Ikechukwu Ugwoke, Michoel Armand, Renaat Kinget, Norbert Verbeke
https://www.ncbi.nlm.nih.gov/pubmed/30981773
Jul 15, 2019 · Here, biomimetic phosphorylcholine-chitosan nanoparticles (PCCs-NPs) taking advantages of both zwitterionic phosphorylcholine and chitosan were developed as a pulmonary protein delivery platform. msFGFR2c, a potential therapeutic protein for lung fibrosis as model was loaded into PCCs-NPs via ionic gelation.Author: Guanglin Zhang, Shanyi Mo, Bangren Fang, Rong Zeng, Ju Wang, Mei Tu, Jianhao Zhao
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
PULMONARY DRUG DELIVERY: A REVIEW . ABOUT AUTHORS: ... Growing attention has been given to the potential of a pulmonary route as an non-invasive administration for systemic delivery of therapeutic agents (mainly peptides and proteins) due to the fact that the lungs provides an big surface area through which molecules can be absorbed and goes ...
https://www.researchgate.net/publication/11666098_The_lung_as_a_route_for_systemic_delivery_of_the_therapeutic_proteins
The lung as a route for systemic delivery of the therapeutic proteins.pdf. ... The architecture of pulmonary delivery system has advantage of large surface area (about 100 m 2 ), ...
https://www.researchgate.net/publication/232051208_Dry_powder_inhalation_systems_for_pulmonary_delivery_of_therapeutic_peptides_and_proteins
Methods: The scope of this review was defined by patent information on DPI devices, formulations and pulmonary delivery of therapeutic peptides and proteins for topical and systemic administration.
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