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https://www.sciencedirect.com/science/article/pii/S0169409X11000408
The process of pulmonary siRNA delivery is summarized in Fig. 1.There are several ways to administer siRNA locally into the lungs. Inhalation is the most common and the easiest method for pulmonary drug delivery and could be applied to siRNA delivery. siRNA for inhalation can be formulated into liquid aerosol or dry powder aerosol.Author: Jenny Ka-Wing Lam, Wanling Liang, Hak-Kim Chan
https://www.sciencedirect.com/science/article/abs/pii/S0169409X11000408
The delivery systems need to be designed carefully in order to maximize the siRNA deposition to the diseased area of the airways. In most of the pulmonary siRNA therapy studies in vivo, siRNA was delivered either intratracheally or intranasally. Very limited work was done on the formulation of siRNA for inhalation which is believed to be the ...Author: Jenny Ka-Wing Lam, Wanling Liang, Hak-Kim Chan
https://www.researchgate.net/publication/50225388_Pulmonary_delivery_of_therapeutic_siRNA
The inhalation route of administration provides local delivery of siRNA therapeutics to the lungs for various pulmonary diseases. A siRNA delivery system can be used to overcome the barriers of ...
https://www.future-science.com/doi/10.4155/tde-2019-0009?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3Dwww.ncbi.nlm.nih.gov
The primary barrier for pulmonary siRNA delivery is the extensively branched structure of the airways with variable lengths and diameters, followed by the presence of lung fluids, such as mucus and surfactant ... Pulmonary delivery of therapeutic siRNA. Adv. Drug Deliv.Author: Rima Kandil, Olivia M Merkel
https://www.future-science.com/doi/abs/10.4155/tde-2019-0012
May 22, 2019 · The selective targeted therapeutic action in diseased organ and least off targeted cytotoxicity are the key benefits of pulmonary delivery. The current review highlights recent developments in pulmonary delivery of siRNA with novel nanosized formulation approach with the proven in vitro/in vivo applications.Author: Denish Bardoliwala, Vivek Patel, Ankit Javia, Saikat Ghosh, Akanksha Patel, Ambikanandan Misra
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665213/
3. Targeted Polymeric Delivery of siRNA for asthma therapy. As summarized in Table 1, pulmonary delivery of siRNA is the most common administration approach for the treatment of experimental asthma, and the majority of the formulations are either naked/modified siRNAs or use lentiviral vectors.Author: Yuran Xie, Olivia M. Merkel
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