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https://www.nejm.org/doi/full/10.1056/NEJMoa035140
Original Article from The New England Journal of Medicine — Prevention of Recurrent Preterm Delivery by 17 Alpha-Hydroxyprogesterone CaproateAuthor: Paul J. Meis, Mark Klebanoff, Elizabeth Thom, Mitchell P. Dombrowski, Baha Sibai, Atef H. Moawad, Ca...
https://www.ncbi.nlm.nih.gov/pubmed/28947068
In general, progesterone is thought to maintain pregnancy through several closely linked mechanisms: (1) promotion of uterine quiescence, (2) inhibition of pro-inflammatory cells, and (3) immunosuppressive action. 17-Alpha hydroxyprogesterone caproate is currently the only medication approved to prevent recurrent preterm birth.Author: Tracy A. Manuck
https://www.ncbi.nlm.nih.gov/pubmed/12802023
Jun 12, 2003 · The results of several small trials have suggested that 17 alpha-hydroxyprogesterone caproate (17P) may reduce the risk of preterm delivery. METHODS: We conducted a double-blind, placebo-controlled trial involving pregnant women with a documented history of …Author: Paul J. Meis, Mark Klebanoff, Elizabeth Thom, Mitchell P. Dombrowski, Baha Sibai, Atef H. Moawad, Ca...
https://www.astho.org/Maternal-and-Child-Health/17P-Fact-Sheet/
17 Alpha-hydroxyprogesterone caproate (17P) Making the Case for 17P . Nearly 500,000 1babies are born preterm in the United States each year. Preterm birth (PTB), or birth less than 37 weeks gestation, puts infants at a higher risk of death and is the leading cause of longterm - …
https://pubchem.ncbi.nlm.nih.gov/compound/Hydroxyprogesterone-caproate
Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate.It is an ester derivative of 17α-hydroxyprogesterone formed from caproic acid (hexanoic acid).Hydroxyprogesterone caproate was previously marketed under the trade name Delalutin by Squibb, which was approved by the U.S. Food and Drug Administration (FDA) in 1956 …
https://clinicaltrials.gov/ct2/show/NCT00331695
May 31, 2006 · Arm A :IM injection of 17 alpha hydroxyprogesterones caproate, 500 mg, twice a week until 36 W or until preterm delivery in high risk symptomatic group and high risk twin pregnancies group. IM injection of 17 alpha-hydroxyprogesterones caproate, 500 mg, once a week until 36 W or until preterm delivery in high risk asymptomatic group.
https://www.smfm.org/publications/280-smfm-statement-use-of-17-alpha-hydroxyprogesterone-caproate-for-prevention-of-recurrent-preterm-birth
Special Delivery e-Newsletter; International Member Newsletter ... Join. Search Search. Home » Publications & Guidelines » SMFM Statement: Use of 17-alpha hydroxyprogesterone caproate for prevention o... SMFM Statement: Use of 17-alpha hydroxyprogesterone caproate for prevention of recurrent preterm birth. Tags: preterm birth, prior preterm ...
https://www.sciencedirect.com/science/article/pii/S0146000514001013
Prevention of preterm delivery with 17-hydroxyprogesterone caproate: Pharmacologic considerations ... et al.Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med, 348 (24) (2003), pp. 2379-2385 ... the effects of 17 alpha-hydroxyprogesterone caproate on embryonic and fetal development and endochondral ...Author: Maisa Feghali, Raman Venkataramanan, Steve Caritis
https://www.sciencedirect.com/science/article/pii/S0002937815026587
Background. Racial/ethnic disparities in preterm birth remain a major public health challenge in the United States. While 17-alpha hydroxyprogesterone caproate (17OHP-C) is recommended for preterm birth prevention in women with a prior preterm birth, non-Hispanic black women continue to experience higher rates of recurrent preterm birth than white women receiving the same treatment.Author: Lynn M Yee, Lilly Y. Liu, Allie Sakowicz, Janelle Renee Bolden, Emily Stinnett Miller
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