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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407659/
In this review, we have discussed various prodrug strategies which have been widely applied for enhancing therapeutic efficacy of ophthalmic drugs. The purpose of this review is to provide an update on the utilization of prodrug concept in ocular drug delivery.Author: Megha Barot, Mahuya Bagui, Mitan R. Gokulgandhi, Ashim K. Mitra
https://www.researchgate.net/publication/226643830_Prodrug_approaches_to_ophthalmic_drug_delivery
To control ocular drug delivery, the O-butyryl ester prodrug of tilisolol (BUTL) and the O-palmitoyl ester prodrug of tilisolol (PalTL) were incorporated into an ophthalmic insert.
https://link.springer.com/chapter/10.1007/978-0-387-49785-3_4
Abstract. Ophthalmic medications are administered either systematically or locally to the eye. In order to treat ocular disorders, the topical delivery of eye drops into the lower cul-de-sac of the eye is preferred since the drug effects are localized and less drug enters into the systemic circulation (i.e., systemic side effects are minimized).Author: Tomi Järvinen, Riku Niemi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061492/
Ophthalmic Drug Delivery Systems for the Treatment of Retinal Diseases: Basic Research to Clinical Applications. ... 90% of ophthalmic drug formulations are for topical drop use. Methods of topical drug delivery include eye drops, ointments, suspensions, contact lenses, and some drug delivery devices. ...Author: Henry F. Edelhauser, Cheryl L. Rowe-Rendleman, Michael R. Robinson, Daniel G. Dawson, Gerald J. Chad...
https://www.sciencedirect.com/science/article/pii/S1818087613000305
Furthermore, prodrug, soft-drug and the chemical delivery system (CDS) are other chemical approaches for improving ophthalmic drug delivery by improving drug penetration across the cornea. It has been estimated that only 1–2% (or less) of an instilled dose of ocular drugs penetrates the inner eye, with the remaining dose reaching the systemic ...Author: Tiantian Ye, Kun Yuan, Wenji Zhang, Shuangshuang Song, Fen Chen, Xinggang Yang, Shujun Wang, Jianwei...
https://www.researchgate.net/publication/224834657_Prodrug_Strategies_in_Ocular_Drug_Delivery
Prodrug Strategies in Ocular Drug Delivery. ... As prodrug approaches can mitigate these limitations, we compared the protective properties of the Cur prodrug curcumin diethyl disuccinate (CurDD ...
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