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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751454/
Feb 05, 2008 · Prodrug approaches are used to improve drug delivery and targeting in the CNS, and utilize passive drug uptake processes into CNS by chemically modifying a drug to become more lipophilic. Such chemical derivatives include, for example, “traditional” lipophilic esters and other lipophilic compounds that release brain-trapped intermediates ...Author: Jarkko Rautio, Krista Laine, Mikko Gynther, Jouko Savolainen
https://www.researchgate.net/publication/5404956_Prodrug_Approaches_for_CNS_Delivery
This review provides insight into various prodrug strategies explored to date for CNS drug delivery, including lipophilic prodrugs, carrier- and receptor-mediated prodrug delivery systems, and ...
https://www.researchgate.net/publication/226270880_Prodrug_Approaches_for_Drug_Delivery_to_the_Brain
A focus of this review is the prodrug approaches based on the utilization of these enzymes for bioconversion and the value of these approaches in achieving selectivity in delivery. View Show abstractAuthor: Bradley D. Anderson
https://link.springer.com/article/10.1208%2Fs12248-008-9009-8
Feb 05, 2008 · This review provides insight into various prodrug strategies explored to date for CNS drug delivery, including lipophilic prodrugs, carrier- and receptor-mediated prodrug delivery systems, and gene-directed enzyme prodrug therapy.Author: Jarkko Rautio, Krista Laine, Mikko Gynther, Jouko Savolainen
https://link.springer.com/chapter/10.1007%2F978-0-387-49785-3_17
Deguchi Y, Hayashi H, Fujii S, Naito T, Yokoyama Y, Yamada S and Kimura R. Improved Brain Delivery of a Nonsteroidal Anti-Inflammatory Drug with a Synthetic Glyceride Ester: A Preliminary Attempt at a CNS Drug Delivery System for the Therapy of Alzheimer’s Disease.Author: Bradley D. Anderson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026551/
May 10, 2014 · This article reviews the current approaches to open or facilitate penetration across these barriers for enhanced drug delivery to the CNS. These approaches are summarized into three broad categories: noninvasive, invasive, and miscellaneous techniques. ... the prodrug method is used to make a drug more lipophilic. ... in BBB and BCSFB ...Author: Cui-Tao Lu, Ying-Zheng Zhao, Ho Lun Wong, Jun Cai, Lei Peng, Xin-Qiao Tian
https://www.sciencedirect.com/topics/medicine-and-dentistry/prodrug
Prodrug is a common approach for achieving tissue-specific drug delivery and reducing toxic side effects. As a case in point, tumor microenvironment (TME), which is characterized by acidic pH, elevated temperature, and overexpressed proteases, provide a useful target for triggering the activation of …
https://www.mdpi.com/1999-4923/11/7/349/htm
Previously, we studied 1,4-dihydropyridine (DHP)-based prodrugs which provided enhanced brain delivery of the parent agents compared to those of simple prodrugs [16,17,18]. However, several shortcomings associated with this approach prompted us to …Author: Katalin Prokai-Tatrai, Daniel L. De La Cruz, Vien Nguyen, Benjamin P. Ross, Istvan Toth, Laszlo Prok...
https://www.mdpi.com/1999-4923/11/7/349/pdf
brain delivery of the parent agents compared to those of simple prodrugs [16–18]. However, several shortcomings associated with this approach prompted us to seek alternative brain-targeting prodrug approaches. Specifically, tractability issues owing to the intrinsic sensitivities of DHPs to oxidation,Author: Katalin Prokai-Tatrai, Daniel L. De La Cruz, Vien Nguyen, Benjamin P. Ross, Istvan Toth, Laszlo Prok...
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