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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751454/
Feb 05, 2008 · Prodrug approaches are used to improve drug delivery and targeting in the CNS, and utilize passive drug uptake processes into CNS by chemically modifying a drug to become more lipophilic. Such chemical derivatives include, for example, “traditional” lipophilic esters and other lipophilic compounds that release brain-trapped intermediates ...Author: Jarkko Rautio, Krista Laine, Mikko Gynther, Jouko Savolainen
https://link.springer.com/article/10.1208%2Fs12248-008-9009-8
Feb 05, 2008 · This review provides insight into various prodrug strategies explored to date for CNS drug delivery, including lipophilic prodrugs, carrier- and receptor-mediated prodrug delivery systems, and gene-directed enzyme prodrug therapy.Author: Jarkko Rautio, Krista Laine, Mikko Gynther, Jouko Savolainen
https://www.researchgate.net/publication/5404956_Prodrug_Approaches_for_CNS_Delivery
This review provides insight into various prodrug strategies explored to date for CNS drug delivery, including lipophilic prodrugs, carrier- and receptor-mediated prodrug delivery systems, and ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026551/
May 10, 2014 · Different strategies for efficient CNS delivery have been studied. This article reviews the current approaches to open or facilitate penetration across these barriers for enhanced drug delivery to the CNS. These approaches are summarized into three broad categories: noninvasive, invasive, and miscellaneous techniques.Author: Cui-Tao Lu, Ying-Zheng Zhao, Ho Lun Wong, Jun Cai, Lei Peng, Xin-Qiao Tian
https://www.researchgate.net/profile/Mikko_Gynther/publication/5404956_Prodrug_Approaches_for_CNS_Delivery/links/00b49528dc279760c9000000.pdf
Prodrug Approaches for CNS Delivery 93 bearing in mind that prodrugs, while not common, may alter the tissue distribution, efficacy and the toxicity of the parent
https://www.slideshare.net/atul_thakur85/prodrug-approaches-for-cns-delivery-ppt-finished-copy
Jul 09, 2012 · Prodrug approaches for cns delivery ppt finished copy 1. PRODRUG APPROACHES FORCNS DRUG DELIVERYReview Article By : Jarkko Rautio, Krista Laine, Mikko Gynther, And Jouko Savolainen Published In The AAPS Journal, Vol. 10, No. 1, March 2008 Seminar Presented by Atulkumar Thakur 1st Year M.Pharm Department of Pharmaceutics MSRCP
https://www.academia.edu/26111470/Prodrug_Approaches_for_CNS_Delivery
Prodrug Approaches for CNS Delivery
https://www.sciencedirect.com/science/article/pii/B9780124166035000043
This chapter describes novel approaches and formulations in the delivery of biologics to the central nervous system (CNS). We begin by discussing the increasing global burden of CNS disorders as well as providing an overview of the current market share of pharmaceuticals for CNS indications.Author: Pankaj Karande, John Philip Trasatti, Divya Chandra
https://www.mdpi.org/molecules/papers/13051035.pdf
Molecules 2008, 13 1036 used to explore prodrug approaches with improved brain delivery. The feasibility of CNS uptake of appropriately designed prodrugs via these transporters is described in detail.
http://if-pan.krakow.pl/pjp/pdf/2013/1_1.pdf
Prodrug approaches for enhancing administration, permeability, absorption, and distribution of drugs Prodrugs with increased aqueous solubility Poor aqueous solubility is considered as a serious problem limiting the therapeutic use of numerous drugs and drug candidates. Among various strategies used to overcome this drawback is the prodrug ap ...
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