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https://www.researchgate.net/publication/236006801_Prodrug_Approach_to_Better_Drug_Delivery
The present article discusses about prodrug incorporated delivery system, ideal properties, limitation and targeting of prodrug.Introduction:The drug gives pharmacologic response by binding with ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273601/
Dec 29, 2015 · Another type of carrier-linked prodrug is the macromolecular prodrug; these prodrugs use polymeric backbones as carriers. Macromolecular prodrugs are commonly used to design prodrugs that will be cleaved inside of a cell and in targeted drug-delivery systems. This approach offers improved drug solubility, stability, drug release and ...Author: Daniela Hartmann Jornada, Guilherme Felipe Dos Santos Fernandes, Diego Eidy Chiba, Thais Regina Ferr...
https://www.sciencedirect.com/topics/medicine-and-dentistry/prodrug
Prodrug is a common approach for achieving tissue-specific drug delivery and reducing toxic side effects. As a case in point, tumor microenvironment (TME), which is characterized by acidic pH, elevated temperature, and overexpressed proteases, provide a useful target for triggering the activation of …
https://www.researchgate.net/publication/285513647_Prodrug_A_novel_approach_of_drug_delivery
We use cookies to make interactions with our website easy and meaningful, to better understand the use of our services, and to tailor advertising. ... Prodrug: A novel approach of drug delivery.
https://www.wiley.com/en-us/Prodrugs+and+Targeted+Delivery%3A+Towards+Better+ADME+Properties-p-9783527326037
Barriers to Ocular Drug Delivery Influx and Efflux Transporters on the Eye Transporter-Targeted Prodrug Approach Drug Disposition in Ocular Delivery Effect of Physiochemical Factors on Drug Disposition in Eye Prodrug Strategy to Improve Ocular Bioavailability (Nontransporter-Targeted Approach) Recent Patents and Marketed Ocular Prodrugs
https://www.genengnews.com/insights/the-prodrug-opportunity-making-good-drugs-better/
Jul 19, 2017 · The prodrug approach seeks to create enhanced versions of already-known pharmacological agents and leverage those enhancements to increase the marketability of the drug.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751454/
Feb 05, 2008 · Here again, the CNS drug delivery via prodrugs can be compromised because of premature systemic bioconversion of the prodrug, although structural requirements for transporter recognition are fulfilled. By using the prodrug approach, BBB penetration properties of a drug molecule can be enhanced without modifying its pharmacological properties ...Author: Jarkko Rautio, Krista Laine, Mikko Gynther, Jouko Savolainen
https://www.powershow.com/viewfl/ce166-ZDc1Z/Prodrugs_An_alternative_approach_for_better_delivery_of_drugs_powerpoint_ppt_presentation
better prodrug design, predicting fate of a prodrug and design of better prodrug. 41 Conclusion. Prodrug development is an exciting and fruitful field ; It can be used for better and novel delivery ; Cost effective comparison to new drug development ; It can be useful in optimizing drug utilization and delivery ; It offers an alternative to the ...
https://www.mdpi.com/1420-3049/19/10/16489/pdf
transport of the drug (as per the mode rn prodrug approach). The investig ators concluded that this prodrug is a promising carrier system to enhance CNS drug delivery ability into brain [28]. 3. The Modern Prodrug Approach The molecular revolution has allowed for a …Author: Arik Dahan, Ellen M. Zimmermann, Shimon Ben-Shabat
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527633166
Dec 15, 2010 · Prodrugs and Targeted Delivery: Towards Better ADME Properties, Volume 47. Editor(s): ... the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. ... (AAPS) Prodrug Focus Group in 2005. Professor Rautio's research focuses on chemistry-based methods ...
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