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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969484/
Jan 23, 2014 · INTRODUCTION TO MDI FORMULATION TECHNOLOGY. In 1956, Riker Laboratories (later acquired by 3M Pharmaceuticals) introduced the first pressurized metered dose inhaler (MDI), Medihaler Epi™, for the management of asthma and chronic obstructive pulmonary disease (COPD) ().Upon introduction of the MDI, medical treatment of lung diseases changed significantly.Author: Paul B. Myrdal, Poonam Sheth, Stephen W. Stein
https://www.ondrugdelivery.com/dry-powder-inhalers-towards-effective-affordable-sustainable-respiratory-healthcare/
Inhaled drug delivery is established as the primary choice for airway disease treatment and continues to hold high potential for systemic drug delivery. Since its invention in the 1950s, the pressurised metered dose inhaler (pMDI) has been the inhaled therapy “gold standard” 1 for airway diseases such as asthma, as a result of being easy to ...
https://www.pharmamanufacturing.com/articles/2015/efficient-development-of-generic-metered-dose-inhalers/
Jun 03, 2015 · Like many drug delivery technologies, development of Metered Dose Inhalers (MDIs) is a technical challenge. Formulators must ensure that the finished product is safe, efficacious for the duration of the product shelf life, and that it complies with the requirements of the current regulatory landscape.
https://www.ondrugdelivery.com/wp-content/uploads/2018/11/Nov2005.pdf
completion of the dose delivery blow, the nasal/oral connection returns to its normal open state (see figure 1). This delivery method holds the potential to become the dominant delivery principle in nasal drug delivery. Direct-Haler is the first drug deliv-ery company to take advantage of this device-dependent reflex for enhancing nasal drug ...
http://www.pharmtech.com/extractables-and-leachables-testing-inhaled-medicines
Jun 02, 2017 · Africa Studio/shutterstock.com Orally inhaled and nasal drug product (OINDP) formulations, which are primarily a propellant including an organic solvent, have a high potential for the leaching of substances from the delivery device components. In this context, a device such as a dry powder inhaler (DPI) or pressurized metered dose inhaler (pMDI) is considered a primary packaging …
https://medlineplus.gov/ency/patientinstructions/000041.htm
Using a metered-dose inhaler (MDI) seems simple. But many people do not use them the right way. ... How to use an inhaler - no spacer. Using a metered-dose inhaler (MDI) seems simple. But many people do not use them the right way. ... Laube BL, Dolovich MB. Aerosols and aerosol drug delivery systems. In: Adkinson NF Jr, Bochner BS, Burks AW, ...
https://drug-dev.com/a-next-generation-inhaled-dry-powder-delivery-platform/
Traditional inhaled drug delivery has used a number of technologies, including pressurized metered dose inhalers (pMDIs), nebulizers, and dry powder inhalers (DPIs). While delivery of drugs via these first-generation inhaled drug systems provides great advantages over oral or intravenous delivery, these systems also have inherent limitations.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969498/
Dec 20, 2013 · INTRODUCTION TO MDI HARDWARE TECHNOLOGY. Since the commercialization of the first metered dose inhaler (MDI) more than a half century ago, MDIs have become the most widely used delivery system for the treatment of lung diseases such as asthma and chronic obstructive pulmonary disease (COPD).Author: Stephen W. Stein, Poonam Sheth, P. David Hodson, Paul B. Myrdal
https://www.iso.org/obp/ui/#!iso:std:41989:en
ISO 20072:2009(en) × ISO 20072:2009(en) ... to the design, labelling, instructions for use and testing requirements for hand-held single- and multi-use aerosol drug delivery devices (ADDDs) intended to deliver a metered or pre-metered aerosolized medication to or by means of the human respiratory tract (including nasal, oral, tracheal ...
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