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https://www.ncbi.nlm.nih.gov/pubmed/32130023
Mar 16, 2020 · For this reason, there are several ongoing technical innovations to improve inhaler devices.Areas covered: Progress in pulmonary drug delivery device technology is examined, focusing on innovations in pressurized metered dose inhalers, dry powder inhalers, nebulizers, and soft mist inhalers.Expert opinion: Both formulation improvements and new ...Author: Mario Cazzola, Francesco Cavalli, Omar S Usmani, Paola Rogliani
https://en.wikipedia.org/wiki/Jet_injector
A jet injector is a type of medical injecting syringe device used for a method of drug delivery known as jet injection, in which a narrow, high-pressure stream of liquid penetrates without needle the outermost layer of the skin (stratum corneum) to deliver medication to targeted underlying tissues of the epidermis or dermis ("cutaneous" injection, also known as classical "intradermal ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352788/
Nebulizers versus pressurized metered-dose inhalers in preschool children with wheezing ... with medication administration by using a spacer with an appropriate mouthpiece or face mask will also improve drug delivery. ... Pressurized metered-dose inhalers with spacers are portable and better tolerated when compared with nebulizers.Author: Christine Smith, Ran D. Goldman
https://clinicalgate.com/pulmonary-drug-delivery/
Pressurized metered-dose inhalers (pMDIs), also referred to as metered-dose inhalers (MDIs), were introduced in the mid-1950s and are the most commonly used inhalation drug delivery devices. In pMDIs, drug is either dissolved or suspended in liquid propellant(s) together with other excipients, including surfactants, and presented in a ...
https://www.liebertpub.com/doi/10.1089/jamp.2015.1232
Pressurized metered-dose inhalers (pMDIs) are sometimes viewed as old-fashioned and as having been superseded by dry powder inhalers (DPIs). Here, we review the technological advances that characterize modern pMDIs, and consider how they can influence the effectiveness of drug delivery for patients with asthma and chronic obstructive pulmonary disease.Author: N. Roche, P.N.R. Dekhuijzen
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/metered-dose-inhaler
Yousef Javadzadeh, Shadi Yaqoubi, in Nanostructures for Drug Delivery, 2017. 6.2 Metered Dose Inhaler (MDI) Metered-dose inhaler is an inhaler device with specified doses that provides a certain dose of the active agent in each puff. MDIs consist of a suspension or dispersion of one or more active ingredient in propellant or a mixture of propellants or a mixture of solvent and propellants, are ...
https://www.aarc.org/wp-content/uploads/2015/04/aerosol_guide_rt.pdf
1 A Guide to Aerosol Delivery Devices for Respiratory Therapists, 4th Edition American Association for Respiratory Care, © 2017 The Science of
https://www.aarc.org/wp-content/uploads/2018/03/aersol-guides-for-hcp.pdf
Drug-Delivery Technique While spacers and VHCs provide many benefits for opti-mal drug delivery with pMDIs, there are also potential prob-lems with their use (see Table 9). Improper technique may decrease drug delivery or, in some cases, cause the dose to be lost. Possible causes of decreased drug delivery include multiple actuations into Table 9.
https://www.sciencedirect.com/science/article/pii/S0954611117303360
A series of experiments testing the consistency and robustness of co-suspension delivery technology-based drug delivery demonstrated highly reproducible dose delivery and aerosol performance, with >99% of doses remaining within the target dose range, and no differences detected between monotherapy and combination product drug delivery .Author: Gary T. Ferguson, Anthony J. Hickey, Sarvajna Dwivedi
http://www.rcjournal.com/contents/09.05/09.05.1177.pdf
Drug Delivery From Spacer Devices Summary The pressurized metered-dose inhaler (pMDI) was introduced to deliver asthma medications in a convenient and reliable multi-dose presentation. The key components of the pMDI device (propel-lants, formulation, metering valve, and actuator) all play roles in the formation of the spray, and
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