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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161132/
Pressurized olfactory delivery (POD) device construction and characterization. The overall construction of the POD nasal aerosol device is diagrammed in Figure 1. A pressurized nitrogen gas supply was connected to a standard two-valve pressure regulator.Author: John D. Hoekman, Rodney J. Y. Ho
http://www.businesswire.com/news/home/20120614006168/en/Impel-NeuroPharma-Announces-Commercial-Milestones-First-in-Human-Pressurized
Jun 14, 2012 · Impel NeuroPharma’s Pressurized Olfactory Delivery (POD) device delivers aerosolized drugs to the upper nasal cavity where they are directly transported into …
https://www.longdom.org/open-access/novel-approach-for-nosetobrain-drug-delivery-bypassing-blood-brain-barrier-by-pressurized-olfactory-delivery-device-.pdf
Pressurized olfactory drug delivery device (POD) is an aerosol nasal spray having a narrow spray plume with circumferential velocity. The gimmick is planned to displace the residual olfactory air volume to deliver therapeutic compound in the olfactory area of the nasal cavity [8].Author: Sudhir Majgainya, Shashank Soni, Priyanka Bhat
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115018/
For evaluation of pharmacokinetics and analgesic effects, we employ a pressurized olfactory drug (POD) delivery device that previously shown to achieve preferential deposition on the upper nasal cavity including olfactory epithelial cells lining nose and brain interface.Author: John D. Hoekman, Pramod Srivastava, Rodney J.Y. Ho
https://www.oindpnews.com/2011/08/pressurized-olfactory-device-study-shows-improved-opiod-delivery/
Aug 24, 2011 · A study by University of Washington researchers published in the September 2011 issue of Anesthesia & Analgesia, the official journal of the International Anesthesia Research Society, demonstrates improved delivery of morphine and fentanyl in rats via a “pressurized olfactory device” (POD) compared to conventional nasal administration.The researchers are also founders of Impel …
https://www.researchgate.net/publication/278850870_Novel_Approach_for_Nose-to-Brain_Drug_Delivery_Bypassing_Blood_Brain_Barrier_by_Pressurized_Olfactory_Delivery_Device
Pressurized olfactory dr ug delivery device (POD) is an aeros ol nasal spray hav ing a narrow spray p lume with circumferential velocity. Th e gimmick is planned to displace the residual olfactory ...
https://blog.foster.uw.edu/impels-pod-device-helps-drugs-jump-the-blood-brain-barrier/
Feb 13, 2012 · It sounds like science fiction: a device that delivers pharmaceutical drugs directly to the brain using something called “nose-to-brain” transport. But this is no sci-fi tale. The Pressurized Olfactory Delivery (POD) device, developed by John Hoekman, UW PhD in pharmaceutics and chief scientific officer of Impel NeuroPharma, has the potential to solve one of the...
https://www.nature.com/articles/npp201461
Mar 17, 2014 · Impel NeuroPharma (Seattle, Washington) has developed a Pressurized Olfactory Delivery (POD) device to specifically deposit a majority of …Author: Virginia Brown, Fang Liu, Fang Liu
https://www.researchgate.net/publication/262941405_Aerosol-Stable_Peptide-Coated_Liposome_Nanoparticles_A_Proof-of-Concept_Study_with_Opioid_Fentanyl_in_Enhancing_Analgesic_Effects_and_Reducing_Plasma_Drug_Exposure
When administered intranasally to rats with the aid of a pressurized olfactory drug delivery device (POD) which preferentially deposits the aerosol to the olfactory region of the nasal cavity, a ...
https://www.sciencedirect.com/science/article/pii/S0022354915304548
Previously, we reported a novel pressurized olfactory drug (POD) delivery device that deposits aerosolized drug preferentially to upper nasal cavity. This POD device provided sustained central nervous system (CNS) levels of soluble morphine analgesic effects.Author: John D. Hoekman, Pramod Srivastava, Rodney J.Y. Ho
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