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https://www.sciencedirect.com/science/article/pii/S0939641110001566
In addition, much effort is still required in order to gain greater insight into the mechanisms that govern the interaction of a carrier with the intestinal membrane and subsequent drug absorption. These are some of the issues which need to be addressed specifically when designing polymeric micelles intended for per oral drug delivery.Author: Geneviève Gaucher, Prashant Satturwar, Marie-Christine Jones, Alexandra Furtos, Jean-Christophe Lero...
https://www.ncbi.nlm.nih.gov/pubmed/20600891
Polymeric micelles for oral drug delivery. Gaucher G(1), Satturwar P, Jones MC, Furtos A, Leroux JC. Author information: (1)Faculty of Pharmacy, University of Montreal, Montreal, Canada H3C 3J7. In the case of chronic therapies, the oral route is often the preferred route for drug administration given its acceptability and convenience.Author: Geneviève Gaucher, Prashant Satturwar, Marie-Christine Jones, Alexandra Furtos, Jean-Christophe Lero...
https://www.sciencedirect.com/science/article/abs/pii/S0939641110001566
Among these factors, poor drug permeability through the GI mucosa and/or low aqueous solubility are of central importance. Polymeric micelles, which form upon self-assembly of amphiphilic macromolecules, can act as vehicles for the oral delivery of these drugs.Author: Geneviève Gaucher, Prashant Satturwar, Marie-Christine Jones, Alexandra Furtos, Jean-Christophe Lero...
https://www.hindawi.com/journals/jdd/2013/340315/
Oral administration is the most commonly used and readily accepted form of drug delivery; however, it is find that many drugs are difficult to attain enough bioavailability when administered via this route. Polymeric micelles (PMs) can overcome some limitations of the oral delivery acting as carriers able to enhance drug absorption, by providing (1) protection of the loaded drug from the harsh ...Author: Wei Xu, Peixue Ling, Tianmin Zhang
https://www.ncbi.nlm.nih.gov/pubmed/17168771
Polymeric micelles for drug delivery. ... Polymeric micelles are nanoscopic core/shell structures formed by amphiphilic block copolymers. Both the inherent and modifiable properties of polymeric micelles make them particularly well suited for drug delivery purposes. An emphasis of this review has been placed on both the description and ...Author: S. R. Croy, G. S. Kwon
https://owndoc.com/pdf/polymeric-micelles-oral-drug-delivery.pdf
gastrointestinal tract. Lastly, with patients preferring the oral drug delivery route to the intravenous delivery route, it was shown that polymeric micelles can achieve the same desired pharmacological dose via either delivery method. These factors make polymeric micelles appear to be a viable option for future oral drug delivery applications. 1.
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