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https://www.sciencedirect.com/science/article/pii/S1381514810001835
1. Introduction. Since application of polymeric micelles as nano-scale drug delivery systems (nano-DDS) in the late 1980s , numerous polymer self-assemblies have been extensively developed aimed to deliver various drugs including; low molecular weight anti-cancer drugs, contrast/imaging agents, proteins, plasmid DNA, antisense DNA, and more recently short interfering RNA (siRNA) , , , .Author: Kanjiro Miyata, R. James Christie, Kazunori Kataoka
https://www.researchgate.net/publication/224872484_Polymeric_micelles_for_nano-scale_drug_delivery
This review describes the design of polymeric micelles from block copolymers and their performances as nano-scale drug delivery systems, with emphasis on our recent work.
https://www.ncbi.nlm.nih.gov/pubmed/17168771
Polymeric micelles for drug delivery. Croy SR(1), Kwon GS. Author information: (1)School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA. Polymeric micelles are nanoscopic core/shell structures formed by amphiphilic block copolymers. Both the inherent and modifiable properties of polymeric micelles make them particularly well ...Author: S. R. Croy, G. S. Kwon
https://www.sciencedirect.com/science/article/abs/pii/S1381514810001835
This review describes the design of polymeric micelles from block copolymers and their performances as nano-scale drug delivery systems, with emphasis on our recent work. The basic drug delivery system platform developed by our group consists of polymeric micelles comprising a core–shell structure with a versatile drug-loading hydrophobic ...Author: Kanjiro Miyata, R. James Christie, Kazunori Kataoka
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639314/
Polymeric micelles are attractive materials for drug delivery applications because their structure can be easily modified and because they can be tailored to deliver a variety of drug cargo including chemotherapeutics, nucleic acids, or imaging agents.Author: Carolyn L. Waite, Charles M. Roth
http://polymermicelles.com/
Additionally however, polymer micelles can be used for drug delivery as the hydrophobic interior has the capacity to hold drugs which are poorly soluble in aqueous solution. This web site discusses just a few uses of polymer micelles as well as the application of PolySciTech products to these uses. Why would a copolymer form a micelle?
https://pubs.rsc.org/en/content/articlelanding/2020/nr/c9nr10574c
9-Nitro-20(S)-camptothecin (9-NC) is a broad-spectrum antitumor drug used in tumor treatments, but its clinical applications and antitumor efficacy are limited by its structural instability, poor solubility, and extremely low drug utilization in tumor tissues.In this study, enzyme-sensitive nuclear-targeted dual-functional polymeric micelles were developed for 9-NC delivery with a high drug ...Author: Yalin Sun, Yan Liang, Na Hao, Xiaoheng Fu, Bin He, Shangcong Han, Jie Cao, Qingming Ma, Wen Xu, Yong...
https://www.hindawi.com/journals/jdd/2013/340315/
Oral administration is the most commonly used and readily accepted form of drug delivery; however, it is find that many drugs are difficult to attain enough bioavailability when administered via this route. Polymeric micelles (PMs) can overcome some limitations of the oral delivery acting as carriers able to enhance drug absorption, by providing (1) protection of the loaded drug from the harsh ...Author: Wei Xu, Peixue Ling, Tianmin Zhang
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