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https://www.sciencedirect.com/science/article/pii/S016777991830060X
Polymeric carriers have emerged as major non-viral alternatives for gene delivery due to their lower immunogenicity and pathogenicity. However, during intracellular delivery of these carriers, multiple barriers have to be overcome or the efficiency of gene delivery will be impeded.Author: Wing-Fu Lai, Wing-Fu Lai, Wing-Tak Wong
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449975/
Apr 28, 2017 · Recent Advances in Nanomaterials for Gene Delivery—A Review. Michael K. Riley ... protein and peptide-based nanoparticles, as well as nanoscale polymeric materials. They have as advantages over viral vectors a decreased immune response, and additionally offer flexibility in design, allowing them to be functionalized and targeted to specific ...Author: Michael K. Riley, Wilfred Vermerris
https://www.sciencedirect.com/science/article/pii/S0168365919306108
In general, polymeric delivery systems do not cause an immune response like those seen for viral vectors [23,24] and, due to the development of controlled polymerization techniques, the ease with which polymeric delivery systems can be modified make them a …Author: Anna Kargaard, Anna Kargaard, Joost P.G. Sluijter, Bert Klumperman
https://www.nature.com/articles/nrd1775
Jul 01, 2005 · Dash, P. R. et al. Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and …Author: Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton
https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.201900213
This review presents an overview of polymeric nonviral carriers with immune cell transfection ability and their potential applications in cancer immunotherapy; it also provides a tutorial for designing polymeric immune‐cell genetic modification vector, although there are still few vectors in the product pipeline. ... polymeric nonviral gene ...Author: Lingjie Ke, Pingqiang Cai, Yun‐Long Wu, Xiaodong Chen
https://www.amazon.com/Polymeric-Gene-Delivery-Principles-Applications/dp/084931934X
Polymeric Gene Delivery: Principles and Applications accentuates the versatility of polymeric delivery systems, including the potential for biocompatibility, the ability to design their formulation and geometry for a specific purpose, and the ease of modification to the surface of polymeric carriers.Author: Mansoor M. Amiji
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480422/
Mar 13, 2017 · Polymeric nanoparticles have been used to address the major limitations of the gene delivery process, such as poor cell uptake, lysosomal degradation, poor transfection efficiency, and off-target effects [27–29]. In this review, we discuss different polymeric nanoparticles for …Author: Narsireddy Amreddy, Anish Babu, Ranganayaki Muralidharan, Anupama Munshi, Rajagopal Ramesh
https://www.thefreelibrary.com/Polymeric+delivery+systems+in+biotechnology%3a+a+mini+review.-a0169211139
Jul 01, 2007 · Implantables, micro and nanoparticulate systems in which the agent is encapsulated for nuclear delivery will have great implications in the success of recent treatment modalities like gene therapy, RNA interference and antisense oligonucleotide based gene silencing. This review compares delivery from viral vectors with non viral polymeric ...
https://link.springer.com/article/10.1007/s41061-017-0128-5
Mar 13, 2017 · Polymeric nanoparticles are more widely used in gene delivery systems than other types of nanoparticles. Their physicochemical properties, such as easy manipulation of particle size, surface charge, and the availability of many functional groups that can be exploited for conjugating different biomolecules and targeting ligands [], make polymeric nanoparticles attractive carriers.Author: Narsireddy Amreddy, Anish Babu, Ranganayaki Muralidharan, Anupama Munshi, Rajagopal Ramesh
http://onlinelibrary.wiley.com/doi/10.1002/adma.200801478/abstract
This Review focuses on the recent progress and challenges facing materials design for nonviral DNA vaccine drug delivery systems. In particular, we highlight work on new polymeric materials and their effects on protective immune activation, gene delivery, and current efforts to optimize polymeric delivery systems for DNA vaccination.
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