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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756366/
1. Introduction. The success of a gene therapy will largely depend on the activity induced by the target genes and the efficiency of gene delivery resulting from the combined effects of the delivery vector and the applied delivery route (Figure 1).Here we present a narrative review that summarizes the recent knowledge on the use of gene therapy for the treatment of pancreatic cancer.Author: Cristina Fillat, Anabel Jose, Xavier Bofill-Deros, Ana Mato-Berciano, Maria Victoria Maliandi, Lucia...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188890/
Oct 07, 2014 · Core tip: This paper tries to present a full picture of gene therapy in pancreatic cancer, providing an unambiguous classification and comprehensive analysis, especially in therapeutic targets and clinical trials worldwide. From our work, you may find the hotspots in related research and the reason why they get there.Author: Si-Xue Liu, Zhong-Sheng Xia, Ying-Qiang Zhong
https://www.researchgate.net/publication/38036554_Pancreatic_cancer_Gene_therapy_approaches_and_gene_delivery_systems
This article summarizes an update of gene therapy approaches and reviews the latest progress in gene delivery systems that have been tested on pancreatic cancer.
https://www.sciencedirect.com/science/article/pii/S0960740401000111
With approximately two-thirds of all gene therapy trials worldwide directed at cancer, the gene therapy approaches that are currently being explored for pancreatic cancer are specifically examined. Gene delivery systems, genetic targets, and combined gene delivery with chemotherapy are discussed in the context of pancreatic cancer treatment.Author: C.M Halloran, P Ghaneh, J.P Neoptolemos, E Costello
https://www.researchgate.net/publication/270013165_Gene_Therapy_of_Pancreatic_Cancer
Different approaches of gene therapy in pancreatic cancers: (a) the vector carries the wild type (WT) version of a tumor suppressor gene lost in the tumor (b) The expression of an oncogene active ...
https://mdanderson.elsevierpure.com/en/publications/pancreatic-cancer-gene-therapy-approaches-and-gene-delivery-syste
Areas covered in this review: This article summarizes an update of gene therapy approaches and reviews the latest progress in gene delivery systems that have been tested on pancreatic cancer. What the reader will gain: The treatment effectiveness of gene combination therapy is better than that of the regulation of single-gene or single gene ...Author: Jin Xu, Chen Jin, Sijie Hao, Guopei Luo, Deliang Fu
https://www.mdpi.com/2072-6694/3/1/368/htm
In the current review, a detailed analysis of the different targets, the delivery vectors, the preclinical approaches and a descriptive update on the conducted clinical trials are presented. Moreover, future possibilities in pancreatic cancer treatment by gene therapy strategies are discussed.Author: Cristina Fillat, Anabel Jose, Xavier Bofill-Deros, Ana Mato-Berciano, Maria Victoria Maliandi, Lucia...
https://www.mdpi.com/2072-6694/3/1/368
The continuous identification of molecular changes deregulating critical pathways in pancreatic tumor cells provides us with a large number of novel candidates to engineer gene-targeted approaches for pancreatic cancer treatment. Targets—both protein coding and non-coding—are being exploited in gene therapy to influence the deregulated pathways to facilitate cytotoxicity, enhance the ...Author: Cristina Fillat, Anabel Jose, Xavier Bofill-Deros, Ana Mato-Berciano, Maria Victoria Maliandi, Lucia...
https://www.sciencedaily.com/releases/2007/07/070709121311.htm
Jul 11, 2007 · A molecularly engineered therapy selectively embeds a gene in pancreatic cancer that shrinks or eradicates tumors, inhibits metastasis, and prolongs survival with virtually no toxicity ...
https://www.liebertpub.com/doi/abs/10.1089%2F104303404322959551
Although effective gene therapy vectors have been developed for organ systems such as the liver, an effective delivery vector to the pancreas in vivo has remained elusive. Of the currently available viral vectors, adenovirus and adeno-associated virus (AAV) are two of the most efficient at transducing nondividing cells.Author: Alfred Y. Wang, Peter D. Peng, Anja Ehrhardt, Theresa A. Storm, Mark A. Kay
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