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https://www.researchgate.net/publication/38036554_Pancreatic_cancer_Gene_therapy_approaches_and_gene_delivery_systems
Suicide gene therapy has been shown to be an effective means of destroying pancreatic cancer cells, but cell-specific delivery of the gene is required to limit host toxicity.
https://mdanderson.elsevierpure.com/en/publications/pancreatic-cancer-gene-therapy-approaches-and-gene-delivery-syste
title = "Pancreatic cancer: Gene therapy approaches and gene delivery systems", abstract = "Importance of the field: Due to the absence of early diagnosis, the highly invasive and metastatic features and the lack of effective therapeutic modalities, the prognosis of patients with pancreatic cancer …Author: Jin Xu, Chen Jin, Sijie Hao, Guopei Luo, Deliang Fu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188890/
Oct 07, 2014 · Viral vectors are main gene delivery tools in gene therapy of cancer, and especially, oncolytic virus shows brighter prospect due to its tumor-targeting property. Efficient therapeutic targets for gene therapy include tumor suppressor gene p53 , mutant oncogene K-ras , anti-angiogenesis gene VEGFR , suicide gene HSK-TK , cytosine deaminase and cytochrome p450 , multiple cytokine genes …Author: Si-Xue Liu, Zhong-Sheng Xia, Ying-Qiang Zhong
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756366/
Pancreatic Cancer Gene Therapy: From Molecular Targets to Delivery Systems 1. Introduction. The success of a gene therapy will largely depend on the activity induced by... 2. Target Genes. A large number of genes have been tested for their therapeutic efficacy... 3. Gene Delivery Vectors. The ...Author: Cristina Fillat, Anabel Jose, Xavier Bofill-Deros, Ana Mato-Berciano, Maria Victoria Maliandi, Lucia...
https://www.mdpi.com/2072-6694/3/1/368/htm
Main delivery routes in gene therapy applications. Representative image of a pancreatic tumor and metastatic foci in the liver. The distribution of the vector into the tumor mass from the main delivery routes is represented in the three right panels. Red lines indicate tumor vasculature.Author: Cristina Fillat, Anabel Jose, Xavier Bofill-Deros, Ana Mato-Berciano, Maria Victoria Maliandi, Lucia...
https://www.mdpi.com/2072-6694/3/1/368
The continuous identification of molecular changes deregulating critical pathways in pancreatic tumor cells provides us with a large number of novel candidates to engineer gene-targeted approaches for pancreatic cancer treatment. Targets—both protein coding and non-coding—are being exploited in gene therapy to influence the deregulated pathways to facilitate cytotoxicity, enhance the ...Author: Cristina Fillat, Anabel Jose, Xavier Bofill-Deros, Ana Mato-Berciano, Maria Victoria Maliandi, Lucia...
https://www.nature.com/articles/cgt201273
Oct 26, 2012 · Ras mutations are present in ∼95% of pancreatic cancer (PC) cases leading to increased proliferation and apoptosis resistance. The aim of this study is to selectively kill Ras-transformed cells by overexpressing the pro-apoptotic protein, p53 upregulated modulator of apoptosis (PUMA) under a Ras-responsive promoter.Author: V Lisiansky, V Lisiansky, I Naumov, I Naumov, S Shapira, S Shapira, D Kazanov, A Starr, A Starr, N A...
https://www.researchgate.net/publication/10986663_Gene_therapy_for_pancreatic_cancer
At least in the short term, it is very likely that success in pancreatic cancer gene therapy will involve therapies that require only the limited transduction of cells.
https://www.sciencedaily.com/releases/2007/07/070709121311.htm
Jul 11, 2007 · A molecularly engineered therapy selectively embeds a gene in pancreatic cancer that shrinks or eradicates tumors, inhibits metastasis, and prolongs survival with virtually no toxicity, researchers from The University of Texas M. D. Anderson Cancer Center report in …
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