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https://link.springer.com/chapter/10.1007%2F978-0-387-25842-3_9
Gene Delivery Gene Carrier Ethyl Methacrylate Chitosan Oligomer Nonviral Gene Delivery These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.Author: Kam W. Leong
https://www.sciencedirect.com/science/article/pii/B9780128144701000101
DNA packaging is a first and prerequisite step for successful gene therapy. 28 For cationic polymer-based gene delivery systems, upon mixing of polymers with DNA, nanosized and compacted polyplexes are formed spontaneously within minutes through electrostatic interactions between the negative phosphate groups along the DNA backbone and positive charges displayed on the polymers…Author: Dezhong Zhou, Ming Zeng, Yongsheng Gao, A. Sigen, Jing Lyu, Wenxin Wang
https://pubs.acs.org/doi/full/10.1021/bm101354a
Protein−polymer conjugates were investigated as nonviral gene delivery vectors. BSA-poly(dimethylamino) ethyl methacrylate (PDMA) nanoparticles (nBSA) were synthesized using in situ atom transfer radical polymerization (in situ ATRP) and BSA as a macroinitiator. The diameter and charge of nBSA was a function of the ATRP reaction time and ranged from 5 to 15 nm and +8.9 to +22.5, …Author: Jianjun Zhang, Yuguo Lei, Anandika Dhaliwal, Quinn Kt Ng, Juanjuan Du, Ming Yan, Yunfeng Lu, Tatiana...
https://pubs.acs.org/doi/pdf/10.1021/bm101354a
Protein−polymer conjugates were investigated as nonviral gene delivery vectors. BSA-poly(dimethylamino) ethyl methacrylate (PDMA) nanoparticles (nBSA) were synthesized using in situ atom transfer radical polymerization (in situ ATRP) and BSA as a macroinitiator.
https://www.researchgate.net/publication/339911951_Polymeric_Nonviral_Gene_Delivery_Systems_for_Cancer_Immunotherapy
Evidence has demonstrated that the rational design of polymeric nonviral gene vectors with optimal structure, charge density, biocompatibility, and stimulus responsiveness can deliver therapeutic...
https://www.sciencedirect.com/science/article/pii/S0168365918301202
Very few polymers have been developed as gene delivery systems specifically for primary human T cells. Low molecular weight PEI (5 kDa) has been conjugated to transferrin to increase uptake of siRNA in activated primary T cells, which resulted in 50% gene silencing [19,20].Author: Brynn R. Olden, Yilong Cheng, Jonathan L. Yu, Suzie H. Pun
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782077/
Oct 16, 2009 · The nonviral gene delivery methods, on the other hand, use synthetic or natural compounds or physical forces to deliver a piece of DNA into a cell. The materials used are generally less toxic and immunogenic than the viral counterparts.Author: Mohammed S. Al-Dosari, Xiang Gao
https://onlinelibrary.wiley.com/doi/pdf/10.1002/adtp.201900213
Evidence has demonstrated that the rational design of polymeric nonviral gene vectors with optimal structure, charge density, biocompatibility, and stimulus responsiveness can deliver therapeutic genes or gene vaccines (in terms of deoxyribonucleic acid DNA or ribonucleic acid RNA) into tumor‐associated immunocytes (i.e., macrophages, T cells, or dendritic cells) in an effective and controllable manner for …Author: Lingjie Ke, Pingqiang Cai, Yun‐Long Wu, Xiaodong Chen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490629/
Numerous biomaterials have been studied as potential nonviral gene delivery vectors to enable improved DNA stability and uptake including inorganic surfaces, cationic lipids, polysaccharides, cationic polymers, and dendrimers. 5,6 These biomaterials either bind to, complex with, or encapsulate DNA into systems that are comparatively easier to manufacture and scale-up than viral systems, although they have orders of magnitude lower efficacy. To rationally design …Author: Jordan J. Green, Robert Langer, Daniel G. Anderson
https://www.mdpi.com/1420-3049/22/4/566/pdf
Biodegradable Poly(Amino Ester) with Aromatic Backbone as Efficient Nonviral Gene Delivery Vectors. Qiang Liu, Rong-Chuan Su, Wen-Jing Yi * and Zhi-Gang Zhao *. College of Chemistry and Environmental Protection Engineering, Southwest Minzu University, Chengdu 610041, China; [email protected] (Q.L.); [email protected] (R.-C.S.)Author: Qiang Liu, Rong-Chuan Su, Wen-Jing Yi, Zhi-Gang Zhao
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