We have collected information about Polymer Delivery Systems For Site-Specific Genome Editing for you. Follow the links to find out details on Polymer Delivery Systems For Site-Specific Genome Editing.
https://www.sciencedirect.com/science/article/pii/S0168365911003063
Here, we review our novel solution to the problem of intracellular delivery of PNA and DNA molecules for genome editing. Poly(lactic-co-glycolic acid) (PLGA) is an FDA-approved biocompatible polymer used clinically for delivery of drugs for numerous indications including treatment of prostate cancer (Lupron ® …Author: Nicole Ali McNeer, Erica B. Schleifman, Peter M. Glazer, W. Mark Saltzman
https://www.researchgate.net/publication/51173095_Polymer_delivery_systems_for_site-specific_genome_editing
Here, we review the use of engineered biodegradable polymer nanoparticles for site-specific genome editing in human hematopoietic cells, which represent a promising approach for ex vivo and in ...
https://www.sciencedirect.com/science/article/pii/S016836592030167X
Genome editing of mutant KRAS through supramolecular polymer-mediated delivery of Cas9 ribonucleoprotein for colorectal cancer therapy. ... the delivery of Cas9 and sgRNA that selectively recognizes the mutant sequence can disrupt the mutant KRAS alleles in a site-specific manner, ...Author: Tao Wan, Tao Wan, Yuxuan Chen, Qi Pan, Xiaojie Xu, Yu Kang, Xue Gao, Feihe Huang, Chuanbin Wu, Yuan ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881452/
Hence, delivery systems for plasmids, having entered into clinical trials including cationic liposomes, cationic polymers, and lipopolymers which are the synthetic complexes of lipids and polymers, are theoretically available for the delivery of genome editing systems (NCT01455389, NCT00595088, NCT01118052, etc., Table 1) .Author: Luyao Wang, Fangfei Li, Lei Dang, Chao Liang, Chao Wang, Bing He, Jin Liu, Defang Li, Xiaohao Wu, Xu...
https://www.ncbi.nlm.nih.gov/pubmed/30957918
Upon laser exposure, the nanocomplex of SPPF and CRISPR/Cas9 cassettes induces effective site-specific precise genome editing both in vitro and in vivo with minimal toxicity. Besides, NIR-II imaging based on SPPF can also be applied to monitor the in vivo distribution of the genome-editing system and guide laser irradiation in real time.Author: Ling Li, Ling Li, Zhen Yang, Shoujun Zhu, Liangcan He, Wenpei Fan, Wei Tang, Jianhua Zou, Zheyu Shen...
https://www.researchgate.net/publication/319709531_Efficient_gene_editing_via_non-viral_delivery_of_CRISPR-Cas9_system_using_polymeric_and_hybrid_microcarriers
CRISPR-Cas9 is a revolutionary genome-editing technology that has enormous potential for the treatment of genetic diseases. However, the lack of efficient and safe, non-viral delivery systems has ...
https://www.nature.com/articles/s41578-019-0145-9
Oct 04, 2019 · In vivo genome editing requires delivery systems that are efficient, safe and tissue specific. This Review outlines the materials and delivery …Author: Sheng Tong, Sheng Tong, Buhle Moyo, Ciaran M. Lee, Kam Leong, Gang Bao
https://www.nature.com/articles/gt201282
Oct 18, 2012 · McNeer, N., Schleifman, E., Cuthbert, A. et al. Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific …Author: Nicole A. McNeer, Erica B. Schleifman, Amy Cuthbert, Michael Brehm, Andrew Jackson, Christopher Chen...
https://link.springer.com/article/10.1007%2Fs11427-017-9022-1
May 01, 2017 · These technologies have opened up a new era for crop improvement due to their precise editing of user-specified sequences related to agronomic traits. In this review, we will focus on an update of recent developments in the methodologies of editing reagent delivery, and consider the pros and cons of current delivery systems.Author: Yidong Ran, Zhen Liang, Caixia Gao
https://saltzmanlab.yale.edu/publications
In utero nanoparticle delivery for site-specific genome editing. ... Glazer PM, Saltzman WM. Polymer delivery systems for site-specific genome editing. J Control Release. 2011 May 18. [Epub ahead of print] ... (BCNU) in the rabbit brain following interstitial delivery by biodegradable polymer implants, Journal of Pharmacology and Experimental ...
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