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https://link.springer.com/chapter/10.1007%2F978-0-387-25842-3_9
Gene Delivery Gene Carrier Ethyl Methacrylate Chitosan Oligomer Nonviral Gene Delivery These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.Author: Kam W. Leong
https://www.sciencedirect.com/science/article/pii/S0168365918301202
The clinical success of chimeric antigen receptor (CAR) T cell immunotherapy in treating multiple blood cancers has created a need for efficient methods of ex vivo gene delivery to primary human T cells for cell engineering. Here, we synthesize and evaluate a panel of cationic polymers for gene delivery to both cultured and primary human T cells.Author: Brynn R. Olden, Yilong Cheng, Jonathan L. Yu, Suzie H. Pun
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782077/
Oct 16, 2009 · The nonviral gene delivery methods, on the other hand, use synthetic or natural compounds or physical forces to deliver a piece of DNA into a cell. The materials used are generally less toxic and immunogenic than the viral counterparts.Author: Mohammed S. Al-Dosari, Xiang Gao
https://www.sciencedirect.com/science/article/pii/B9780128144701000101
However, polymer gene delivery vectors have shown some promise in targeting certain diseases. Indeed, viral vectors are more efficient but safety is a significant concern. Polymer gene delivery vectors have not elicited any substantial toxicity or immune responses in various clinical trials.Author: Dezhong Zhou, Ming Zeng, Yongsheng Gao, A. Sigen, Jing Lyu, Wenxin Wang
https://pubs.acs.org/doi/10.1021/cr800409e
Dec 03, 2008 · Nonviral Gene Delivery with Cationic Glycopolymers. ... Design, Synthesis, and Cellular Uptake of Oligonucleotides Bearing Glutathione-Labile Protecting Groups. ... Protein−Polymer Nanoparticles for Nonviral Gene Delivery. Biomacromolecules 2011, 12 (4) , 1006-1014. DOI: 10.1021/bm101354a. ...Author: Meredith A. Mintzer, Eric E. Simanek
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490629/
Nonviral gene delivery systems make use of physical methods or a synthetic chemical vector or both to deliver the gene of interest. Limitations with viral approaches, including small cargo capacity, resistance to repeated infection, difficulty in production and quality control, and low safety, can be potentially overcome with a nonviral approach.Author: Jordan J. Green, Robert Langer, Daniel G. Anderson
https://pubs.acs.org/doi/10.1021/acs.accounts.8b00665
The full potential of polymer-based delivery systems has yet to be realized, however, because most polymeric transfection reagents are either too inefficient or too toxic for use in the clinic. In this Account, we describe developments in carbohydrate-based cationic polymers, termed glycopolymers, for enhanced nonviral gene delivery.Author: Craig Van Bruggen, Joseph K. Hexum, Zhe Tan, Rishad J. Dalal, Theresa M. Reineke
https://vtechworks.lib.vt.edu/handle/10919/50926
Mechanisms for cellular internalization of polymer-nucleic acid complexes are important for the future design of nucleic acid delivery vehicles. It is well known that the mammalian cell surface is covered with glycosaminoglycans (GAG) that carry a negative charge.
https://www.researchgate.net/publication/339911951_Polymeric_Nonviral_Gene_Delivery_Systems_for_Cancer_Immunotherapy
With the rapid growth of immunotherapy in cancer treatment and knowledge accumulation in vector structure design, polymeric nonviral gene delivery systems may provide new hope for tumor therapy ...
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