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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912992/
Introduction. Drug delivery systems (DDSs) are important for effective, safe, and convenient administration of drugs. pH- and ion-responsive polymers have been widely employed in DDS for site-specific drug release due to their abilities to exploit specific pH- or ion-gradients in the human body.Author: Takayuki Yoshida, Tsz Chung Lai, Glen S Kwon, Kazuhiro Sako
https://www.sciencedirect.com/science/article/pii/S1001841720301200
Materials such as pH sensitive polymers, peptides and inorganic materials (include metal and nonmetal), are used to fabricate protonation mechanism-based pH-sensitive drug delivery systems , each of which exists different properties and will be discussed in the following part.Author: Zhaoqing Shi, Qianqian Li, Lin Mei, Lin Mei
https://www.researchgate.net/publication/257800537_pH-sensitive_polymers_for_drug_delivery
Another approach of pH-controlled drug delivery is a variety of pH-sensitive polymers 5. A further approach to targeted drug release are magnetizable implants and functionalized magnetic carriers ...
https://www.sciencedirect.com/science/article/pii/S0169409X06001839
3. pH-responsive polymers in drug delivery. The pH is an important signal, which can be addressed through pH-responsive materials. The physiological pH changes have been mentioned earlier . Ionisable polymers with a pK a value between 3 and 10 are candidates for pH-responsive systems . Weak acids and bases like carboxylic acids, phosporic acid ...Author: Dirk Schmaljohann
https://link.springer.com/article/10.1007%2Fs13233-012-0059-5
Mar 29, 2012 · Various pH-sensitive polymers have been developed for biomedical applications and recently attracted much attention for pH targeting nanomedicine. Recent development of pH-sensitive polymer systems that sharply respond to specific pH environment in solid tumors and cells and demonstrate modulated properties (e.g., triggered drug release at extratumoral pH, ligands or cell …Author: Kang Moo Huh, Han Chang Kang, Young Ju Lee, You Han Bae
https://www.ncbi.nlm.nih.gov/pubmed/23930949
Polymers with pH-sensitive chemical linkages, such as hydrazone, acetal, ortho ester and vinyl ester, pH-sensitive cell-penetrating peptides and cationic polymers undergoing pH-dependent protonation have been studied to utilize the pH gradient along the endocytic pathway for intracellular drug delivery. As ion-sensitive polymers, ion-exchange ...Author: Takayuki Yoshida, Tsz Chung Lai, Glen S Kwon, Kazuhiro Sako
https://www.mdpi.com/2073-4360/11/11/1834
This work demonstrates a simple approach for coating a porous polymer layer on stainless-steel (SS) microneedles characterized by a pH-responsive formulation for self-regulated drug delivery. For many drug-delivery applications, the release of therapeutic agents in an acidic microenvironment is desirable. Acid-sensitive polymers and hydrogels were extensively explored, but easily prepared ...Author: Asad Ullah, Haroon Khan, Hye Jin Choi, Gyu Man Kim
https://www.researchgate.net/publication/330496117_PH_Responsive_Polymers_in_Drug_Delivery
PH Responsive Polymers in Drug Delivery. ... of mesoporous silica nanoparticles as pH-sensitive drug delivery . vehicles for cancer therapy. Journal of Colloid and Interface .
https://www.mdpi.com/2073-4360/9/4/137/pdf-vor
enlighten readers on the role of pH sensitive hydrogels in drug delivery, their mechanism of action, swelling, and drug release as a function of pH change along the GI tract. The basis for the selection of materials, their structural features, physical and chemical properties, the presence of ionic pendant groups, and the influence of their ...
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