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https://www.researchgate.net/publication/280263920_pH-sensitive_siRNA_delivery_systems
The cytoplasmic membrane of endosomal-lysosomal compartments is the final barrier for effective cytosolic siRNA delivery. pH-sensitive siRNA delivery systems have been designed to overcome this ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081533/
Oct 27, 2016 · Simultaneous delivery of Paclitaxel and Bcl-2 siRNA via pH-Sensitive liposomal nanocarrier for the synergistic treatment of melanoma. Sci. Rep. 6, 35223; doi: 10.1038/srep35223 (2016). Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Author: Teegala Lakshminarayan Reddy, Teegala Lakshminarayan Reddy, Koteswara Rao Garikapati, Koteswara Rao ...
https://www.sciencedirect.com/science/article/pii/S0734975013002140
Among the different types of stimuli, pH sensitive system has been most widely used to design sensitive nano-systems for drug delivery in cancer therapy. It is well known that pH values vary significantly in different tissues or organs, such as stomach and liver, and in disease states, such as ischemia, infection, inflammation, and tumorigenesis.Author: Juan Liu, Yuran Huang, Anil Kumar, Aaron Tan, Shubin Jin, Anbu Mozhi, Xing-Jie Liang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912992/
Introduction. Drug delivery systems (DDSs) are important for effective, safe, and convenient administration of drugs. pH- and ion-responsive polymers have been widely employed in DDS for site-specific drug release due to their abilities to exploit specific pH- or ion-gradients in the human body.Author: Takayuki Yoshida, Tsz Chung Lai, Glen S Kwon, Kazuhiro Sako
https://www.sciencedirect.com/science/article/pii/S1001841720301200
The mechanisms of pH-sensitive drug delivery systems mainly include pH-sensitive bond cleavage and protonation mechanism, which are theoretical basis for designing smart and responsive drug delivery systems. To date, combination therapy has revealed additive and even synergistic anti-cancer efficacy.Author: Zhaoqing Shi, Qianqian Li, Lin Mei, Lin Mei
https://pubs.acs.org/doi/10.1021/bc100010k
Small interfering RNAs offer novel opportunities to inhibit gene expression in a highly selective and efficient manner but depend on cytosolic translocation with synthetic delivery systems. The polyethylenimine (PEI) is widely used for plasmid DNA transfection. However, the water-soluble PEI does not form siRNA polyplexes stable enough in extracellular media for effective delivery.Author: Gaelle Creusat, Anne-Sophie Rinaldi, Etienne Weiss, Rkia Elbaghdadi, Jean-Serge Remy, Rita Mulherkar...
https://pubs.rsc.org/en/content/articlelanding/2018/bm/c8bm01062e#!
Herein, we developed a facile modular assembly strategy for a pH-sensitive charge reversal siRNA delivery system (PC), which can be easily obtained by adjusting the ratios of positively and negatively charged modules. This PC is electronegative at neutral pH and reverses to electropositive at an acidic pH value with increased tumor cellular uptake.
https://pubs.acs.org/doi/abs/10.1021/bc100010k
pH-sensitive siRNA delivery systems. Journal of Drug Delivery Science and Technology 2012, 22 (1) , 55-63. DOI: 10.1016/S1773-2247(12)50005-5. Peter Järver, Thibault Coursindel, Samir EL Andaloussi, Caroline Godfrey, Matthew JA Wood, Michael J Gait. Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA. ...Author: Gaelle Creusat, Anne-Sophie Rinaldi, Etienne Weiss, Rkia Elbaghdadi, Jean-Serge Remy, Rita Mulherkar...
https://www.thno.org/v07p3432.htm
In this work, we tried to improve siRNA delivery potency by rational design of carriers, our data revealed that siRNA endosomal release was more important than endocytosis for successful delivery. The pH-sensitive feature is perfectly matched with enhancing siRNA endosomal release, which could be an important principle for optimizing siRNA ...
http://zcgroup.cpu.edu.cn/_upload/article/files/82/46/d21bd6324211981f6fbced7a9a55/b758d213-3bb0-4b52-acdb-af0d289b0d63.pdf
the currently available siRNA delivery systems still remain ungratified and deficient. Herein, we developed a facile modular assembly strategy for a pH-sensitive charge reversal siRNA delivery system (PC), which can be easily obtained by adjusting the ratios of …
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