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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912992/
Introduction. Drug delivery systems (DDSs) are important for effective, safe, and convenient administration of drugs. pH- and ion-responsive polymers have been widely employed in DDS for site-specific drug release due to their abilities to exploit specific pH- or ion-gradients in the human body.Author: Takayuki Yoshida, Tsz Chung Lai, Glen S Kwon, Kazuhiro Sako
https://www.sciencedirect.com/science/article/pii/S0734975013002140
Among the different types of stimuli, pH sensitive system has been most widely used to design sensitive nano-systems for drug delivery in cancer therapy. It is well known that pH values vary significantly in different tissues or organs, such as stomach and liver, and in disease states, such as ischemia, infection, inflammation, and tumorigenesis.Author: Juan Liu, Yuran Huang, Anil Kumar, Aaron Tan, Shubin Jin, Anbu Mozhi, Xing-Jie Liang
https://www.sciencedirect.com/science/article/pii/S1001841720301200
pH-Sensitive drug delivery systems can deliver anticancer drugs under acidic tumor microenvironment. Commonly, there are two mechanisms that explain the essence of pH-sensitivity of systems: acid sensitive chemical bond cleavage and protonation of materials. ... The most popular pyridine groups containing polymer are poly(2-vinyl pyridine) (pK ...Author: Zhaoqing Shi, Qianqian Li, Lin Mei, Lin Mei
https://pubs.acs.org/doi/10.1021/ja207150n
Efficient delivery of therapeutics into tumor cells to increase the intracellular drug concentration is a major challenge for cancer therapy due to drug resistance and inefficient cellular uptake. Herein, we have designed a tailor-made dual pH-sensitive polymer–drug conjugate nanoparticulate system to …Author: Jin-Zhi Du, Xiao-Jiao Du, Cheng-Qiong Mao, Jun Wang
https://link.springer.com/article/10.1007%2Fs13233-012-0059-5
Mar 29, 2012 · Various pH-sensitive polymers have been developed for biomedical applications and recently attracted much attention for pH targeting nanomedicine. Recent development of pH-sensitive polymer systems that sharply respond to specific pH environment in solid tumors and cells and demonstrate modulated properties (e.g., triggered drug release at extratumoral pH, ligands or cell …Author: Kang Moo Huh, Han Chang Kang, Young Ju Lee, You Han Bae
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149454/
Aug 10, 2011 · A novel cell-targeting, pH-sensitive polymeric carrier was employed in this study for delivery of the anticancer drug bortezomib (BTZ) to cancer cells. Our strategy is based on facile conjugation of BTZ to catechol-containing polymeric carriers that are ...Author: Jing Su, Feng Chen, Vincent L. Cryns, Phillip B. Messersmith
https://www.onlinelibrary.wiley.com/doi/10.1002/marc.201800917
The use of acetals (Figure 5D) as pH‐sensitive linkages for drug delivery was first reported by Fréchet and co‐workers in 2004. 72 Important work in this area was based on …Author: Nayeleh Deirram, Changhe Zhang, Sarah S. Kermaniyan, Angus P. R. Johnston, Georgina K. Such
https://www.mdpi.com/2073-4360/9/4/137/pdf-vor
drug residence time owing to their mucoadhesive and bioadhesive properties which make them very good vehicles for drug delivery [16,22]. The beauty of natural polymers is that they are non-toxic, biodegradable, biocompatible, abundant, and cheap. However, natural polymer based hydrogels are poor in mechanical strength.
https://pubs.acs.org/doi/10.1021/bm700517z
Oct 16, 2007 · We report the development and characterization of pH-sensitive poly(2-tetrahydropyranyl methacrylate) [poly(THPMA)] nanospheres and demonstrate their feasibility as an effective drug delivery vehicle. Poly(THPMA) nanospheres were prepared using either the double emulsion or single emulsion method for the encapsulation of, respectively, water soluble (rhodamine B) or organic soluble …Author: Jua Jung, In-Hyun Lee, Eunhye Lee, Jinho Park, Sangyong Jon
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