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https://www.sciencedirect.com/science/article/pii/S0169409X01002034
For this reason, either pH-sensitive and/or temperature-sensitive hydrogels can be used for site-specific controlled drug delivery. Hydrogels that are responsive to specific molecules, such as glucose or antigens, can be used as biosensors as well as drug delivery systems.Author: Yong Qiu, Kinam Park
https://pubs.rsc.org/en/content/articlehtml/2012/ra/c2ra20989f
In vitro drug release behavior was investigated using VB 12 and paclitaxel (PTX) as model drugs, revealing that the P(LE-IA-MEG) hydrogel could control the diffusion of the drug. The prepared new kind of pH-sensitive hydrogel with great pH-responsiveness and good properties for drug delivery might have great potential application in smart drug ...Author: Ke Wang, Qiang Fu, Xi Chen, Yang Gao, Kai Dong
https://www.mdpi.com/2073-4360/9/4/137/htm
The presence of an acidic group on the PAA chains makes it a suitable candidate for use as a pH sensitive hydrogel for drug delivery. The p K a of PAA is between 4.5 and 5.0 and at pH > 5, acidic moieties become ionized developing a negative charge on the pendant groups of the polymer chains. This negative charge causes severe repulsion between ...Author: Muhammad Rizwan, Rosiyah Yahya, Aziz Hassan, Muhammad Yar, Ahmad Danial Azzahari, Vidhya Selvanathan...
https://www.sciencedirect.com/science/article/pii/S0032386108000487
Hydrogels in drug delivery: Progress and challenges ... a highly cross-linked interpenetrating network of a pH-sensitive hydrogel and a hydrolysable hydrogel restricts the typically rapid swelling response of a pH ... His current work focuses on the development of injectable hydrogels for drug delivery, hydrogel coatings for regulating the ...Author: Todd R. Hoare, Daniel S. Kohane
https://www.mdpi.com/2073-4360/9/4/137/pdf
enlighten readers on the role of pH sensitive hydrogels in drug delivery, their mechanism of action, swelling, and drug release as a function of pH change along the GI tract. The basis for the selection of materials, their structural features, physical and chemical properties, the presence of ionic pendant groups, and the influence of their ...Author: Muhammad Rizwan, Rosiyah Yahya, Aziz Hassan, Muhammad Yar, Ahmad Danial Azzahari, Vidhya Selvanathan...
https://www.ncbi.nlm.nih.gov/pubmed/30633578
Development of novel pH-sensitive nanoparticles loaded hydrogel for transdermal drug delivery. ... ocular, vaginal and topical delivery of drug molecules. However, pH-sensitive potential of this polymer has not been explored for transdermal delivery. The aim of this research work was to exploit the pH-sensitive potential of ES100 as a ...Author: Maimoona Qindeel, Naveed Ahmed, Fakhara Sabir, Samiullah Khan, Asim Ur-Rehman
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