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https://www.sciencedirect.com/science/article/pii/S0734975013002140
Among the different types of stimuli, pH sensitive system has been most widely used to design sensitive nano-systems for drug delivery in cancer therapy. It is well known that pH values vary significantly in different tissues or organs, such as stomach and liver, and in disease states, such as ischemia, infection, inflammation, and tumorigenesis.Author: Juan Liu, Yuran Huang, Anil Kumar, Aaron Tan, Shubin Jin, Anbu Mozhi, Xing-Jie Liang
https://www.researchgate.net/publication/224937599_pH_Sensitive_Drug_Delivery_Systems_A_Review
pH Sensitive Drug Delivery Systems (PSDDS) are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved ...
https://scialert.net/fulltext/?doi=ajdd.2011.24.48
pH sensitive systems: Controlled drug delivery systems, which are intended to deliver drugs at predetermined rates for predefined periods of time, have been used to overcome the shortcomings of conventional drug formulations. Although, significant progress has been made in the controlled drug delivery area, more advances are yet to be made for ...
https://scialert.net/abstract/?doi=ajdd.2011.24.48
Drug pharmacokinetics can also be pH-sensitive; therefore, variations both in a disease state and in drug plasma concentration need to be taken into consideration in developing drug delivery systems intended for the treatment of disease with adequate dose.
https://www.tandfonline.com/doi/abs/10.3109/08982109409037050
Jun 01, 2015 · Cholesterol hemisuccinate is a particularly attractive component for in vivo use since it stabilizes the liposome when in serum at pH 7.4. The use of pH sensitive liposomes in drug delivery should continue to expand due to the increasing number of macromolecular therapeutic agents with intracellular targets.Author: Chun-Jung Chu, Francis C. Szoka
https://www.sciencedirect.com/science/article/abs/pii/S0734975013002140
Herein, this review mainly focuses on pH-sensitive nano-systems, including advances in drug delivery, mechanisms of drug release, and possible improvements in drug absorption, with the emphasis on recent research in this field.Author: Juan Liu, Yuran Huang, Anil Kumar, Aaron Tan, Shubin Jin, Anbu Mozhi, Xing-Jie Liang
https://www.ncbi.nlm.nih.gov/pubmed/29113804
Jan 15, 2018 · Coupling a specific stimuli-triggered drug release mechanism with these delivery systems is one of the most prevalent approaches for targeted therapy. Among these approaches, pH-sensitive micelles are regarded as the most general strategy with advantages of increasing solubility of water-insoluble drugs, pH-sensitive release, high drug loading ...Author: Zhe Wang, Xiangping Deng, Jinsong Ding, Wenhu Zhou, Xing Zheng, Guotao Tang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912992/
Introduction. Drug delivery systems (DDSs) are important for effective, safe, and convenient administration of drugs. pH- and ion-responsive polymers have been widely employed in DDS for site-specific drug release due to their abilities to exploit specific pH- or ion-gradients in the human body.Author: Takayuki Yoshida, Tsz Chung Lai, Glen S Kwon, Kazuhiro Sako
https://www.researchgate.net/publication/232257568_Drug_delivery_systems_An_updated_review
Drug delivery systems: An updated review. ... including coating dr ugs with pH-sensitive and . ... Synthesis and characterization of a pH responsive and mucoadhesive drug delivery system for the ...
https://link.springer.com/article/10.1007%2Fs13233-012-0059-5
Mar 29, 2012 · Various pH-sensitive polymers have been developed for biomedical applications and recently attracted much attention for pH targeting nanomedicine. Recent development of pH-sensitive polymer systems that sharply respond to specific pH environment in solid tumors and cells and demonstrate modulated properties (e.g., triggered drug release at extratumoral pH, ligands or cell …Author: Kang Moo Huh, Han Chang Kang, Young Ju Lee, You Han Bae
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