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https://www.researchgate.net/publication/224937599_pH_Sensitive_Drug_Delivery_Systems_A_Review
pH Sensitive Drug Delivery Systems (PSDDS) are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient therapeutic efficacy and compliance.
https://scialert.net/fulltext/?doi=ajdd.2011.24.48
pH Sensitive Drug Delivery Systems (PSDDS) are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient therapeutic efficacy and compliance.
https://scialert.net/abstract/?doi=ajdd.2011.24.48
Abstract: pH Sensitive Drug Delivery Systems (PSDDS) are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient therapeutic efficacy and compliance.
https://www.sciencedirect.com/science/article/pii/S0734975013002140
Among the different types of stimuli, pH sensitive system has been most widely used to design sensitive nano-systems for drug delivery in cancer therapy. It is well known that pH values vary significantly in different tissues or organs, such as stomach and liver, and in disease states, such as ischemia, infection, inflammation, and tumorigenesis.Author: Juan Liu, Yuran Huang, Anil Kumar, Aaron Tan, Shubin Jin, Anbu Mozhi, Xing-Jie Liang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · a. pH Sensitive Polymer Coated Drug Delivery to the Colon . In the stomach, pH ranges between 1 and 2 during fasting but increases after eating.18 The pH is about 6.5 in the proximal small intestine, and about 7.5 in the distal small intestine.19 From the ileum to the colon, pH declines significantly. It is about 6.4 in the cecum.Author: Anil K. Philip, Betty Philip
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912992/
Drug delivery systems (DDSs) are important for effective, safe, and convenient administration of drugs. pH- and ion-responsive polymers have been widely employed in DDS for site-specific drug release due to their abilities to exploit specific pH- or ion-gradients in the human body.Author: Takayuki Yoshida, Tsz Chung Lai, Glen S Kwon, Kazuhiro Sako
https://pubs.acs.org/doi/10.1021/la3015767
Because the drug conjugate includes a low-pH labile bond, i.e., benzoic imine, the permeability of the coassembled polymeric vesicles can be tuned by changing either the PLL-CA/PEG-DOX weight ratio or the environmental pH from 7.4 to 6.5. Furthermore, at lower pH …
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