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https://www.sciencedirect.com/science/article/pii/S0734975013002140
Among the different types of stimuli, pH sensitive system has been most widely used to design sensitive nano-systems for drug delivery in cancer therapy. It is well known that pH values vary significantly in different tissues or organs, such as stomach and liver, and in disease states, such as ischemia, infection, inflammation, and tumorigenesis.Author: Juan Liu, Yuran Huang, Anil Kumar, Aaron Tan, Shubin Jin, Anbu Mozhi, Xing-Jie Liang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912992/
Introduction. Drug delivery systems (DDSs) are important for effective, safe, and convenient administration of drugs. pH- and ion-responsive polymers have been widely employed in DDS for site-specific drug release due to their abilities to exploit specific pH- or ion-gradients in the human body.Author: Takayuki Yoshida, Tsz Chung Lai, Glen S Kwon, Kazuhiro Sako
https://www.sciencedirect.com/science/article/pii/S0141813018357994
3. pH-sensitive CS nanogels for drug delivery 3.1. Anti-cancer drugs. CS has good chelation and adsorption capacity in the drug delivery system, and there are a large number of hydroxyl and amine groups presented in the molecular chain, which make it sensitive to pH.Author: Lei Xing, Ya-Tong Fan, Li-Jun Shen, Chen-Xi Yang, Xiao-Ying Liu, Yan-Ni Ma, Lian-Yu Qi, Ki-Hyun Cho,...
https://www.tandfonline.com/doi/abs/10.3109/08982109409037050
Jun 01, 2015 · Cholesterol hemisuccinate is a particularly attractive component for in vivo use since it stabilizes the liposome when in serum at pH 7.4. The use of pH sensitive liposomes in drug delivery should continue to expand due to the increasing number of macromolecular therapeutic agents with intracellular targets.Author: Chun-Jung Chu, Francis C. Szoka
https://scialert.net/fulltext/?doi=ajdd.2011.24.48
pH Sensitive Drug Delivery Systems (PSDDS) are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient therapeutic efficacy and compliance.
https://link.springer.com/article/10.1007%2Fs13233-012-0059-5
Mar 29, 2012 · Various pH-sensitive polymers have been developed for biomedical applications and recently attracted much attention for pH targeting nanomedicine. Recent development of pH-sensitive polymer systems that sharply respond to specific pH environment in solid tumors and cells and demonstrate modulated properties (e.g., triggered drug release at extratumoral pH, ligands or cell …Author: Kang Moo Huh, Han Chang Kang, Young Ju Lee, You Han Bae
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