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https://www.sciencedirect.com/science/article/pii/S0169409X06001839
3. pH-responsive polymers in drug delivery. The pH is an important signal, which can be addressed through pH-responsive materials. The physiological pH changes have been mentioned earlier . Ionisable polymers with a pK a value between 3 and 10 are candidates for pH-responsive systems . Weak acids and bases like carboxylic acids, phosporic acid ...Author: Dirk Schmaljohann
https://www.onlinelibrary.wiley.com/doi/10.1002/marc.201800917
Stimuli‐responsive nanoparticles have the potential to improve the delivery of therapeutics to a specific cell or region within the body. There are many stimuli that have shown potential for specific release of cargo, including variation of pH, redox potential, or the presence of enzymes. pH variation has generated significant interest for the synthesis of stimuli‐responsive nanoparticles ...Author: Nayeleh Deirram, Changhe Zhang, Sarah S. Kermaniyan, Angus P. R. Johnston, Georgina K. Such
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681499/
Jul 12, 2019 · 2.1. Chitosan. Chitosan as a natural stimuli-responsive polymer is capable of showing both thermo-responsive and pH responsive properties [51,52].The drug delivery systems made of chitosan show relevance to drug delivery applications especially for cancer therapy and skin treatment due to their biocompatibility, biodegradability, and low toxicity [].Author: Sudipta Chatterjee, Patrick Chi-leung Hui
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912992/
Introduction. Drug delivery systems (DDSs) are important for effective, safe, and convenient administration of drugs. pH- and ion-responsive polymers have been widely employed in DDS for site-specific drug release due to their abilities to exploit specific pH- or ion-gradients in the human body.Author: Takayuki Yoshida, Tsz Chung Lai, Glen S Kwon, Kazuhiro Sako
https://www.sciencedirect.com/science/article/pii/B9780081019979000059
5.3. pH-responsive polymer-based drug delivery scaffolds. In the human body, there exists a pH gradient which spans all the way from very acidic to physiological pH value (7.4). Fig. 5.2 shows the variation in pH that is found in the human body at the organ, tissue, and cellular levels . Based on this pH variation, various pH-sensitive DDSs can ...Author: Elaref Ratemi
https://www.onlinelibrary.wiley.com/doi/pdf/10.1002/smll.201602379
Responsive nanomaterials have emerged as promising candidates as drug delivery vehicles in order to address biomedical diseases such as cancer. In this work, polymer‐based responsive nanoparticles prepared by a supramolecular approach are loaded with doxorubicin (DOX) for the cancer therapy.Author: Chung Yen Ang, Chung Yen Ang, Si Yu Tan, Cathleen Teh, Jia Min Lee, Mun Fei Eddy Wong, Qiuyu Qu, Li ...
https://pubs.acs.org/doi/abs/10.1021/mp100253e
Toward the development of the next-generation NPs, researchers have designed novel multifunctional platforms for sustained release, molecular targeting, and environmental responsiveness. This review focuses on environmentally responsive mechanisms used in NP designs, and highlights the use of pH-responsive NPs in drug delivery.Author: Weiwei Gao, Juliana M. Chan, Omid C. Farokhzad
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