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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379544/
Dec 06, 2010 · 4. pH-responsive NPs at the cellular level: intracellular delivery. Following endocytosis, rapid endosomal acidification (~2–3 min) occurs due to a vacuolar proton ATPase-mediated proton influx. As a result, the pH levels of early endosomes, sorting endosomes, and multivesicular bodies drop rapidly to …Author: Weiwei Gao, Juliana M. Chan, Omid C. Farokhzad
https://www.tandfonline.com/doi/full/10.1080/10717544.2017.1279238
Dec 19, 2012 · pH-Responsive drug delivery has been used to preferentially release drugs at sites of disease against bacterial and viral infections. For example, heparin-chitosan NPs were formulated to treat Helicobacter pylori infections (Lin et al., 2009). At pH 1.2–2.5, NPs were self-assembled by the mixing of chitosan and heparin, and remained stable in the gastric lumen owing to electrostatic interactions …Author: Lin Liu, WenDong Yao, YueFeng Rao, XiaoYang Lu, JianQing Gao
https://www.onlinelibrary.wiley.com/doi/10.1002/marc.201800917
The hydrazone linkage (Figure 5A) is one of the most commonly used linkages in pH‐responsive drug delivery systems. At pH 7.4, the hydrazone bond is relatively stable and hydrolyzes very slowly, while in endosomal/lysosomal compartments (pH 5–6), the rate of hydrolysis is increased. 38 Dox and poly(N‐(2‐hydroxypropyl)methacrylamide) (HPMA), a hydrophilic biocompatible polymer, have been …Author: Nayeleh Deirram, Changhe Zhang, Sarah S. Kermaniyan, Angus P. R. Johnston, Georgina K. Such
https://www.researchgate.net/publication/330496117_PH_Responsive_Polymers_in_Drug_Delivery
pH responsive or pH s ensitive polymers used in drug delivery for differe nt p urposes and by d ifferent routes. Commonly studied delivery system containing pH
https://www.tandfonline.com/doi/abs/10.1080/10717544.2017.1279238?tab=permissions
(2017). pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms. Drug Delivery: Vol. 24, No. 1, pp. 569-581.
https://www.sciencedirect.com/science/article/pii/S0169409X06001839
The obvious change in pH along the GI tract from acidic in the stomach (pH = 2) to basic in the intestine (pH = 5–8) has to be considered for oral delivery of any kind of drug, but there are also more subtle changes within different tissue. Certain cancers as well as inflamed or wound tissue exhibit a pH different from 7.4 as it is in circulation.Author: Dirk Schmaljohann
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201900795
However, only limited efforts have been dedicated to engineering such camouflage to endow it with optimized or additional properties, in particular properties critical to a “smart” drug delivery system, such as stimuli‐responsive drug release. A pH‐responsive biomimetic “platesome” for specific drug delivery to tumors and tumor ...Author: Guangna Liu, Guangna Liu, Guangna Liu, Xiao Zhao, Yinlong Zhang, Yinlong Zhang, Junchao Xu, Junchao ...
https://pubs.acs.org/doi/10.1021/acsami.0c01786
Engineered pH-Responsive Mesoporous Carbon Nanoparticles for Drug Delivery Miguel Gisbert-Garzarán Department of Chemistry in Pharmaceutical Sciences, Faculty of Pharmacy, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Plaza Ramón y Cajal s/n, 28040 Madrid, SpainAuthor: Miguel Gisbert-Garzarán, Miguel Gisbert-Garzarán, Julia Catherine Berkmann, Dimitra Giasafaki, Danie...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149454/
Aug 10, 2011 · Targeted drug delivery systems aim to improve the efficacy and reduce the toxicity of potent therapeutics in treatments for a variety of diseases. For example, chemotherapy is one of the major systemic treatments for cancer, but it is linked to serious side effects because of its toxicity to normal proliferating cells.Author: Jing Su, Feng Chen, Vincent L. Cryns, Phillip B. Messersmith
https://pubs.acs.org/doi/abs/10.1021/acsami.8b06114
Biodegradable Cyclomatrix Polyphosphazene Nanoparticles: A Novel pH-Responsive Drug Self-Framed Delivery System Shenglei Hou School of Chemical Science and Engineering, The State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, ChinaAuthor: Shenglei Hou, Shuangshuang Chen, Yuan Dong, Su Gao, Bangshang Zhu, Qinghua Lu
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