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https://www.sciencedirect.com/science/article/pii/S0168365998001515
Various approaches have been used for oral delivery of drug(s) to the colon which include time-dependent delivery, pH-dependent systems and delivery systems that utilise bacteria that colonise the colon or enzymes produced by these bacteria to effect drug release.Author: M.Zahirul I Khan, Željko Prebeg, Nevenka Kurjaković
https://www.sciencedirect.com/topics/nursing-and-health-professions/drug-delivery-system
Colonic-targeted drug delivery is useful for the treatment of inflammatory bowel diseases. In this case, the systems have been developed using pH-dependent delivery, enzyme-dependent delivery (for prodrugs, matrices, and coatings), pulsatile time-dependent delivery, and pressure-dependent delivery approaches (Bansal et al., 2014).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912992/
Introduction. Drug delivery systems (DDSs) are important for effective, safe, and convenient administration of drugs. pH- and ion-responsive polymers have been widely employed in DDS for site-specific drug release due to their abilities to exploit specific pH- or ion-gradients in the human body.Author: Takayuki Yoshida, Tsz Chung Lai, Glen S Kwon, Kazuhiro Sako
https://www.ncbi.nlm.nih.gov/pubmed/10053194
Mar 29, 1999 · A pH-dependent colon targeted oral drug delivery system using methacrylic acid copolymers. I. Manipulation Of drug release using Eudragit L100-55 and Eudragit S100 combinations. Khan MZ(1), Prebeg Z, Kurjaković N.Author: M.Zahirul I Khan, Željko Prebeg, Nevenka Kurjaković
https://www.tandfonline.com/doi/pdf/10.1081/DDC-120003853
At low pH hydration of alginic acid leads to the formation of a high-viscosity ‘‘acid gel.’’ Alginate is ... gel dependent on pH, i.e., an acid gel and an ionotropic gel, gives the polymer ... controlled-release drug delivery system (12,13).
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201806248
Nov 12, 2018 · An antitumor delivery system is designed using a chemotherapy drug and a tumor target molecule covalently linked to cerium oxide nanoparticles (nanoceria). Nanoceria have a unique redox activity in that they possess antioxidant activity at physiological pH but have an intrinsic oxidase activity at acidic pH.Author: Ruijuan Gao, Ruijuan Gao, Rajendra Narayan Mitra, Min Zheng, Kai Wang, Jesse Christine Dahringer, Zo...
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