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https://www.antibodysociety.org/overcoming-antibody-delivery-challenges/
Sep 07, 2017 · In the opening talk of this session, Jasi Atwal (Genentech) will present on bispecific antibodies to increase antibody delivery across the BBB into the brain. One arm of the bispecific binds to a receptor enriched at the BBB, such as transferrin receptor or CD98 heavy chain. The other arm of the bispecific binds to the brain target of interest.
https://www.ncbi.nlm.nih.gov/pubmed/29973504
Jul 04, 2018 · Overview of Antibody Drug Delivery. Awwad S(1)(2), Angkawinitwong U(3). ... Monoclonal antibodies (mAbs) are one of the most important classes of therapeutic proteins, which are used to treat a wide number of diseases (e.g., oncology, inflammation and autoimmune diseases). Monoclonal antibody technologies are continuing to evolve to develop ...Author: Sahar Awwad, Ukrit Angkawinitwong
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161251/
Jul 04, 2018 · The phage display technique can produce expressed antibody motifs, which are often Fab or single-chain variable fragments (scFv) . The pool of the antibody phages creates an antibody library, which is used in the selection process or ‘panning’ step to screen the antibody candidates based on the binding property to target molecules.Author: Sahar Awwad, Ukrit Angkawinitwong
https://www.nature.com/articles/nchem.2779
May 22, 2017 · One of the major obstacles in intracellular targeting using antibodies is their limited release from endosomes into the cytosol. Here we report an approach to deliver …Author: Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, Kentarou Sakamoto, Hao-Hsin Yu, Ikuhiko Nak...
https://pubs.acs.org/doi/10.1021/acs.bioconjchem.9b00025
Realizing the potential for antibody therapy in disease treatment, progress has been made in the development of methods to deliver antibodies intracellularly. In this review, we address various platforms for delivery of antibodies and their merits and drawbacks.Author: Khushboo Singh, Wardah Ejaz, Kingshuk Dutta, S. Thayumanavan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089357/
These results are suggestive of the potential of RMT in enhancing therapeutic antibody delivery to the brain to reducing Aβ plaque burden in AD. The potential for antibody efflux in the brain to blood direction must also be taken into consideration when developing antibody-based diagnostic and therapeutic strategies for CNS cancers.Author: Ann-Marie Chacko, Chunsheng Li, Daniel A. Pryma, Steven Brem, George Coukos, Vladimir R. Muzykantov
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