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https://www.sciencedirect.com/science/article/pii/0169409X9500005R
advanced drug delivery reviews ELSEVIER Advanced Drug Delivery Reviews 15 (1995) 53-72 Antibody delivery through the blood-brain barrier Ulrich Bickel* Institute of Physiology, Philipps-University, Marburg, Deutschhausstr. 2, 35033 Marburg, Germany (Received 10 March 1995; accepted 30 March 1995) Abstract The diagnosis and therapy of diseases of the central nervous system could benefit from the application of highly specific monoclonal antibodies …Author: Ulrich Bickel
https://www.sciencedirect.com/science/article/abs/pii/0169409X9500005R
The diagnosis and therapy of diseases of the central nervous system could benefit from the application of highly specific monoclonal antibodies as drugs. There is, however, the pharmacokinetic problem of delivering these high molecular weight proteins through the blood-brain barrier (BBB).Author: Ulrich Bickel
https://wyss.harvard.edu/technology/brain-targeting-shuttles-for-drug-delivery-and-diagnostics/
Jun 13, 2019 · Antibody-based strategy for delivering drugs and diagnostics across the blood-brain barrier In its Brain Targeting Program, a Wyss team led by Founding Director Donald Ingber, M.D., Ph.D. and Staff Program Lead James Gorman, M.D., Ph.D. is developing improved approaches to target drugs and diagnostics to the brain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089357/
Routes for antibody delivery across the blood-brain barrier (BBB). (A) The brain is comprised of multiple barriers that control access of administered agents into the brain parenchyma, including the BBB. (B) The BBB is comprised of a neurovascular unit ...Author: Ann-Marie Chacko, Chunsheng Li, Daniel A. Pryma, Steven Brem, George Coukos, Vladimir R. Muzykantov
https://www.ncbi.nlm.nih.gov/pubmed/29067674
Biologics include recombinant lysosomal enzymes, neurotrophins, decoy receptors, and therapeutic antibodies. These are large molecule drugs that do not cross the blood-brain barrier (BBB). All classes of biologics have been tested, without success,...Author: William M. Pardridge
https://www.genovis.com/blog/investigating-igg-delivery-across-the-blood-brain-barrier-with-glycinator/
Transcytosis of antibodies across the in vitro blood-brain barrier exhibited non receptor-medicated mechanisms that were unaffected by human FcRn-binding motifs and Fc-glycoforms as demonstrated by the different species and deglycosylated human IgG1.
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