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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089357/
Routes for antibody delivery across the blood-brain barrier (BBB). (A) The brain is comprised of multiple barriers that control access of administered agents into the brain parenchyma, including the BBB. (B) The BBB is comprised of a neurovascular unit ...Author: Ann-Marie Chacko, Chunsheng Li, Daniel A. Pryma, Steven Brem, George Coukos, Vladimir R. Muzykantov
https://www.gene.com/stories/how-to-get-into-the-brain
Dec 01, 2015 · Our scientists have developed a new type of bi-specific antibody that can “piggy-back” on an existing transportation system into the brain. One half of the antibody is designed to take advantage of the existing transport system, the other half is designed to target the abnormal amyloid plaques characteristic of Alzheimer’s disease.
https://wyss.harvard.edu/technology/brain-targeting-shuttles-for-drug-delivery-and-diagnostics/
Jun 13, 2019 · Antibody-based strategy for delivering drugs and diagnostics across the blood-brain barrier In its Brain Targeting Program, a Wyss team led by Founding Director Donald Ingber , M.D., Ph.D. and Staff Program Lead James Gorman , M.D., Ph.D. is developing improved approaches to target drugs and diagnostics to the brain.
https://www.sciencedirect.com/science/article/pii/S0304419X11000400
Stem cell-mediated antibody delivery. A recently identified approach for the delivery of antibodies to cancer in the brain is the use of stem cells as antibody delivery vehicles. Both neural stem cells (NSCs) and mesenchymal stem cells (MSCs) have an inherent tropism to tumors and metastases [87], [88].Author: Richard T. Frank, Karen S. Aboody, Joseph Najbauer
https://www.antibodysociety.org/overcoming-antibody-delivery-challenges/
Sep 07, 2017 · In the opening talk of this session, Jasi Atwal (Genentech) will present on bispecific antibodies to increase antibody delivery across the BBB into the brain. One arm of the bispecific binds to a receptor enriched at the BBB, such as transferrin receptor or CD98 heavy chain. The other arm of the bispecific binds to the brain target of interest. M.
https://www.sciencedirect.com/science/article/pii/0169409X9500005R
Invasive techniques for the delivery of antibodies to the brain are not applicable on a broad basis and for frequent or continous administrations in chronic disease. Osmotic BBB disruption can facilitate brain uptake of antibodies along with other serum proteins, but it …Author: Ulrich Bickel
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