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http://www.sciencedev.net/Docs/book_chapter_final.pdf
research to demonstrate how the antibody-conjugated nanoparticles (NPs) of novel biodegradable copolymers can be developed for targeted chemotherapy by using Herceptin (Trastuzumab®), an only United States Food and Drug Administration (FDA) approved antibody drug, as a model ligand and Docetaxel, one of the best antineoplastic drugs, as a model drug.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249419/
Considerable research is being directed towards developing biodegradable polymeric nanoparticles for drug delivery and tissue engineering, in view of their applications in controlling the release of drugs, stabilizing labile molecules (e.g., proteins, peptides, or DNA…Author: Rajesh Singh, James W. Lillard, James W. Lillard
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302817/
Dec 18, 2018 · Polymeric NPs can solve the drug hydrophobicity problem by dissolving drugs in a polymeric matrix and providing advantages such as high stability, long bloodstream circulation time, targeted space activation, efficient drug load, and sustained drug release.8,9 The targeted DDS can deliver drugs in an active way, which is achieved via coupling effector molecules to the surface of the …Author: Shijie Xu, Fangbo Cui, Dafu Huang, Dinghu Zhang, Anqing Zhu, Xia Sun, Yiming Cao, Sheng Ding, Yao Wa...
https://www.sciencedirect.com/science/article/pii/S0928493115305981
A targeted delivery system based on the polymeric nanoparticles as a drug carrier represents a marvelous avenue for cancer therapy. The pivotal characteristics of this system include biodegradability, biocompatibility, non-toxicity, prolonged circulation and a wide payload spectrum of a therapeutic agent.Author: Farha Masood
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435502/
The use of nanoparticles for targeted drug delivery is often facilitated by specific conjugation of functional targeting molecules to the nanoparticle surface. We compared different biotin binding proteins (avidin, streptavidin, or neutravidin) as crosslinkers to conjugate proteins to biodegradable nanoparticles prepared from PLGA-PEG-biotin polymers.Author: Seth A. Townsend, Gilad D. Evrony, Frank X. Gu, Martin P. Schulz, Robert H. Brown, Robert Langer
https://www.sciencedirect.com/science/article/pii/S0142961207006230
We used biotin-binding proteins to conjugate targeting molecules to the surface of biodegradable nanoparticles for drug delivery . The conjugation method uses biotin-functionalized PLGA-PEG polymers and biotin-binding proteins (avidin, streptavidin, and neutravidin) as crosslinkers for conjugation , , . This system has the advantage of conjugating a targeting ligand to the surface of the …Author: Seth A. Townsend, Gilad D. Evrony, Frank X. Gu, Martin P. Schulz, Robert H. Brown, Robert Langer
https://www.sciencedirect.com/science/article/pii/S001448000800141X
Considerable research is being directed towards developing biodegradable polymeric nanoparticles for drug delivery and tissue engineering, in view of their applications in controlling the release of drugs, stabilizing labile molecules (e.g., proteins, peptides, or DNA) from degradation, and site-specific drug …Author: Rajesh Singh, James W. Lillard, James W. Lillard
https://www.sciencedirect.com/science/article/pii/S0142961210010914
Research on quantitative control of targeting effect for the drug delivery system of ligand-conjugated nanoparticles of biodegradable polymers is at the cutting edge in the design of drug delivery device.Author: Yutao Liu, Kai Li, Bin Liu, Si-Shen Feng
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238292/
Nov 28, 2011 · AM's lab is developing biodegradable nanoparticles for gene and drug delivery and is also participating in a collaborative project with DKS' lab on the use of biodegradable nanoparticles in delivering a HIV- DNA vaccine within the cervical and vaginal mucosa. DKS: is an associate professor of microbiology at the Winston Salem State University.Author: Anil Mahapatro, Dinesh K Singh
https://www.researchgate.net/publication/41850553_Polymeric_Nanoparticles_for_Drug_Delivery
To overcome this predicament, use of natural/synthetic biodegradable polymeric nanoparticles (NPs) have gained prominence in the field of nanomedicine for targeted drug delivery to improve ...
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