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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365085/
Jan 23, 2015 · Nanoparticle delivery systems offer the added strength of multi-component loading which is of considerable significance particularly in immunotherapy where simultaneous delivery of antigens, immunoadjuvants, and targeting ligands is ideal [1–8]. Additionally, due to their large surface area, nanoparticles can be readily surface-engineered with proteins, peptides, polymers, cell …Author: Aliasger K. Salem
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607064/
Mar 25, 2013 · Nanoparticles as vaccine delivery vehicles Traditional vaccines include live attenuated microbes, killed microbes, or components of microbes. Although many of these vaccines have been central to the control of infectious disease, some do not afford good protection against disease.Author: Anthony E. Gregory, Richard Titball, Diane Williamson
https://link.springer.com/article/10.1208/s12248-015-9720-1
Jan 23, 2015 · Nanoparticles in Vaccine Delivery. Part of the following topical collections: Vaccines have been responsible for the effective control or elimination of many potentially fatal diseases. However, many other diseases such as cancers and those caused by intracellular pathogens still lack effective prophylactic or therapeutic vaccines.Author: Aliasger K. Salem
https://www.sciencedirect.com/science/article/pii/B9780323399814000105
Polymer-based nanoparticles constitute a promising delivery system for vaccine antigens and adjuvants, benefiting from numerous properties that promote an efficient priming of the immune response. Next to that, morphology and composition of nanoparticles mimicking key features of pathogens provide them with intrinsic adjuvant properties.Author: L. Lambricht, C. Peres, H. Florindo, V. Préat, G. Vandermeulen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180194/
Oct 04, 2018 · Keywords: nanoparticles, vaccine development, human diseases, targeted vaccine delivery, antigens Introduction In twenty-first Century, infectious diseases have emerged as a serious threat to the health of millions of people across the globe ( 1 ).Author: Rashmirekha Pati, Maxim Shevtsov, Maxim Shevtsov, Avinash Sonawane, Avinash Sonawane
https://www.sciencedirect.com/science/article/pii/S0169409X18301649
The commonly used phage capsids for vaccine delivery are <200 nm, such as Qβ (28 nm) , MS2 (26 nm) , T7 (56 nm) , λ (60 nm) , and T4 (120 × 86 nm) . Therefore, phage VLP vaccines can efficiently enter the lymphatic system and are transported to the lymph nodes to stimulate adaptive immune responses.Author: Pan Tao, Pan Tao, Jingen Zhu, Marthandan Mahalingam, Himanshu Batra, Venigalla B. Rao
https://www.ncbi.nlm.nih.gov/pubmed/31647394
Oct 24, 2019 · Nanotechnology increasingly plays an important role in vaccine development Nanocarrier-based delivery systems offer an opportunity to increase the cellular and humoral immune responses. The use of nanoparticles in vaccine formulations allows not only enhanced immunogenicity and stability of antigen, but also targeted delivery and slow release.Author: Mehdi kheirollahpour, Mohsen Mehrabi, Naser Mohammadpour Dounighi, Mohsen Mohammadi, Alireza Masoudi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833244/
Nov 06, 2019 · Importance of nanoparticle-based vaccine delivery platforms Development of vaccines has made significant impact on reducing the viral infectious disease burden in both humans and animals. However, there are still many diseases for which either we do not have vaccines or need substantial improvements over existing ones [ 36 , 37 ].Author: Santosh Dhakal, Santosh Dhakal, Gourapura J. Renukaradhya, Gourapura J. Renukaradhya
https://www.sciencedirect.com/science/article/pii/S0264410X13016319
Another type of nanoparticles used as adjuvants in vaccines delivery is nano-sized emulsions , , . These nanoparticles can exist as oil-in-water or water-in-oil forms, where the droplet size can vary from 50 nm to 600 nm [128] .
https://pubs.acs.org/doi/abs/10.1021/acs.chemrev.5b00109
Extra-Large Pore Mesoporous Silica Nanoparticles Enabling Co-Delivery of High Amounts of Protein Antigen and Toll-like Receptor 9 Agonist for Enhanced Cancer Vaccine Efficacy. ACS Central Science 2018 , 4 (4) , 484-492.Author: Darrell J. Irvine, Melissa C. Hanson, Kavya Rakhra, Talar Tokatlian
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